Effect of Valproic acid on bone healing in rat

• Material Type: 博士論文
• Title: Effect of Valproic acid on bone healing in rat
• Author/Editor: Rashid, Md.Mamunur
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2013-09-20
• Publication Date (W3CDTF): 2013-09-20
• Alternative Title: Effect of Valproic acid on bone healing in rat; ラット骨欠損治癒におけるバルプロ酸の影響に関する研究
• Degree grantor/type: 新潟大学
• Date Granted: 2013-09-20
• Date Granted (W3CDTF): 2013-09-20
• Dissertation Number: 甲第3817号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第3817号
• Text Language Code: eng
• Subject Heading: bone regeneration; histone deacetylase inhibitors (HDACi); valproic acid (VPA); bone cavity; osteoblast
• Note (General): Objectives: Sufficient bone quality and quantity before placement of dental implant are necessary to achieve successful result. Although numerous materials and methods have been reported regarding bone augmentation, more reliable and feasible ones are still required in this field. Valproic acid (VPA) regulates osteoblast differentiation through Runx2-dependent transcriptional activation. The aim of the present study was to evaluate the effect of systemic administration of VPA on bone regeneration in rat maxillary bone cavity. Materials and Methods: Forty two Wistar rats were divided into control and experimental groups. Upper first and second molars were extracted at the age of 4 weeks. Three weeks after extraction, experimental group received intraperitoneal injection of VPA for 7 days prior to the preparation of bone cavity at the first molar area. Rats were sacrificed on day 3, 7, 14, and 21 and samples were prepared for micro-CT and histological analyses. Serum was used for alkaline phosphatase (ALP) activity measurement. Results: Micro-CT analysis showed higher amount of newly formed bone, bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and less trabecular separation (Tb. Sp) in experimental group than control group. VPA treated animals showed significantly higher ALP activities at 7, 14 and 21 days than control group. According to the histological observations, the amount of newly formed bone was clearly larger in experimental group at 7, 14, and 21 days than control group. rat maxillary bone cavity, it might be useful for the bone augmentation prior to, or upon implant therapy.; 学位の種類: 博士（歯学）. 報告番号: 甲第3817号. 学位記番号: 新大院博（歯）甲第283号. 学位授与年月日: 平成25年9月20日; 新大院博（歯）甲第283号; 開始ページ : 1; 終了ページ : 28
• Persistent ID (NDL): info:ndljp/pid/8948586; https://dl.ndl.go.jp/pid/8948586
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/24558
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp