Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit

• Material Type: 博士論文
• ISSN: 1868-4483
• Title: Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit
• Volume: 4 3
• Author/Editor: Naraoka, Masato; Munakata, Akira; Matsuda, Naoya; Shimamura, Norihito; Ohkuma, Hiroki
• Author Heading: Naraoka, Masato; Munakata, Akira; Matsuda, Naoya; Shimamura, Norihito; Ohkuma, Hiroki
• Publication, Distribution, etc.: Springer
• Publication Date: 2013-01
• Publication Date (W3CDTF): 2013-01
• Periodical title: Translational Stroke Research
• Degree grantor/type: 弘前大学
• Date Granted: 2013-09-30
• Date Granted (W3CDTF): 2013-09-30
• Dissertation Number: 甲第1807号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1807号
• Text Language Code: eng
• Subject Heading: Cerebral vasospasm; Pitavastatin; Fasudil; Rho/Rho-kinase pathway; eNOS; 外科系臨床医学
• NDC: 494.62
• Target Audience: 一般
• Note (General): type:Thesis; The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS.; Open Access Article; identifier:Translational Stroke Research, 4(3), 2013, p.368-374
• DOI: info:doi/10.1007/s12975-012-0247-9; https://doi.org/info:doi/10.1007/s12975-012-0247-9
• Persistent ID (NDL): info:ndljp/pid/8948619; https://dl.ndl.go.jp/pid/8948619
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5109
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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