Osteogenic matrix cell sheet transplantation enhances early tendon graft to bone tunnel healing in rabbits.

• Material Type: 博士論文
• ISSN: 2314-6141
• Title: Osteogenic matrix cell sheet transplantation enhances early tendon graft to bone tunnel healing in rabbits.
• Volume: 2013
• Author/Editor: Inagaki, Yusuke; Uematsu, Kota; Akahane, Manabu; Morita, Yusuke; Ogawa, Munehiro; Ueha, Tomoyuki; Shimizu, Takamasa; Kura, Tomohiko; Kawate, Kenji; Tanaka, Yasuhito
• Author Heading: Inagaki, Yusuke; Uematsu, Kota; Akahane, Manabu; Morita, Yusuke; Ogawa, Munehiro; Ueha, Tomoyuki; Shimizu, Takamasa; Kura, Tomohiko; Kawate, Kenji; Tanaka, Yasuhito
• Publication, Distribution, etc.: Hindawi Pub. Co.
• Publication Date: 2013
• Publication Date (W3CDTF): 2013
• Alternative Title: 骨形成細胞シートを用いた家兎移植腱骨孔間の早期治癒促進
• Periodical title: BioMed research international
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-11-27
• Date Granted (W3CDTF): 2013-11-27
• Dissertation Number: 甲第608号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第608号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; The objective of this study was to determine whether osteogenic matrix cell sheets (OMCS) could induce bone formation around grafted tendons, thereby enhancing early stage tendon to bone tunnel healing in skeletally mature male Japanese white rabbits. First, the osteogenic potential of rabbit OMCS was evaluated. Then, the OMCS were transplanted into the interface between the grafted tendon and the bone tunnel created at the tibia. Histological assessments and biomechanical tensile testing were performed after 3 weeks. The rabbit OMCS showed high alkaline phosphatase (ALP) activity, positive staining of ALP, and osteogenic potential when transplanted subcutaneously with beta tricalcium phosphate disks. Newly formed bony walls and positive collagen type I staining were seen around the grafted tendon with OMCS transplantation, whereas such bony walls were thinner or less frequent without OMCS transplantation. Micro-computed tomography images showed significantly higher bone volume in the OMCS transplantation group. The pullout strength was significantly higher with OMCS (0.74 ± 0.23 N/mm(2)) than without OMCS (0.58 ± 0.15 N/mm(2)). These results show that OMCS enhance early tendon to bone tunnel healing. This method can be applied to cases requiring early tendon to bone tunnel healing after ligament reconstruction surgery.; 博士（医学）・甲第608号・平成25年11月27日; Copyright © 2013 Yusuke Inagaki et al. This is an open access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; identifier:BioMed research international Vol.2013 Article ID:842192; identifier:23146141; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2673; identifier:BioMed research international, 2013: Article ID:842192
• DOI: info:doi/10.1155/2013/842192; https://doi.org/info:doi/10.1155/2013/842192
• Persistent ID (NDL): info:ndljp/pid/8948863; https://dl.ndl.go.jp/pid/8948863
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2673
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-12-07 再収集

2023-12-07 再収集

2023-12-07 再収集