Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction.

• Material Type: 博士論文
• ISSN: 0470-8105
• Title: Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction.
• Volume: 53 3
• Author/Editor: Miyake, Hitoshi; Nakagawa, Ichiro; Takeshima, Yasuhiro; Nishimura, Fumihiko; Park, Young-Su; Nakamura, Mitsutoshi; Nakase, Hiroyuki
• Author Heading: Miyake, Hitoshi; Nakagawa, Ichiro; Takeshima, Yasuhiro; Nishimura, Fumihiko; Park, Young-Su; Nakamura, Mitsutoshi; Nakase, Hiroyuki
• Publication, Distribution, etc.: 日本脳神経外科学会
• Publication Date: 2013; 53 3
• Publication Date (W3CDTF): 2013
• Alternative Title: ラット脳静脈モデルにおける血管内皮増殖因子桔抗薬の虚血後投与
• Periodical title: Neurologia medico-chirurgica
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-11-27
• Date Granted (W3CDTF): 2013-11-27
• Dissertation Number: 乙第1321号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1321号
• Text Language Code: eng
• Subject Heading: cerebral venous infarction; vascular endothelial growth factor; antagonist; brain edema
• Target Audience: 一般
• Note (General): type:Thesis; Cerebral venous ischemia can result in severe brain edema. Inhibition of vascular endothelial growth factor (VEGF) activity by a neutralizing antibody can completely block the hypoxia-induced increase in vascular permeability. VEGF, which induces angiogenesis, also acts as a vascular permeability (VP) factor. We previously showed that inhibition of VEGF attenuates VP and reduces cerebral venous infarction (CVI) in the acute stage. The present study investigated the therapeutic time window during which inhibition of VEGF can reduce CVI in a rat two-vein occlusion (2-VO) model. A 2-VO model was created by photochemically occluding two adjacent cortical veins. Male Wistar rats (n = 42) were assigned to one of four groups: Group 1 was treated with a VEGF antagonist at 24 hours after 2-VO (n = 11); Group 2 was treated with phosphate-buffered solution (PBS) at 24 hours after 2-VO (n = 11); Group 3 was treated with a VEGF antagonist at 48 hours after 2-VO (n = 10); and Group 4 was treated with PBS at 48 hours after 2-VO (n = 10). The developing ischemic infarct was evaluated histologically at 7 days after 2-VO. CVI areas were significantly smaller in Group 1 than in Groups 2, 3, and 4 (p <0.05) but were similar when comparing Groups 3 and 4. Anti-VEGF therapy was effective in reducing CVI in rats if started within 24 hours after 2-VO.; 博士（医学）・乙第1321号・平成25年11月27日; Copyright © 日本脳神経外科学会 | The Japan Neurosurgical Society / 学会誌名（Neurologia medico-chirurgica）とJ-STAGEからの出典である; identifier:Neurologia medico-chirurgica Vol.53 No.3 p.135-140; identifier:04708105; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2676; identifier:Neurologia medico-chirurgica, 53(3): 135-140
• DOI: info:doi/10.2176/nmc.53.135; https://doi.org/info:doi/10.2176/nmc.53.135
• Persistent ID (NDL): info:ndljp/pid/8949104; https://dl.ndl.go.jp/pid/8949104
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2676
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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