Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma

• Material Type: 博士論文
• ISSN: 1341-9625
• Title: Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma
• Volume: 18 4
• Author/Editor: Tovuu, Lkhagva-Ochir; Imura, Satoru; Utsunomiya, Tohru; Morine, Yuji; Ikemoto, Tetsuya; Arakawa, Yusuke; Mori, Hiroki; Hanaoka, Jun; Kanamoto, Mami; Sugimoto, Koji; Iwahashi, Shuichi; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito; Miyake, Hidenori; Shimada, Mitsuo
• Author Heading: Tovuu, Lkhagva-Ochir; Imura, Satoru; Utsunomiya, Tohru; Morine, Yuji; Ikemoto, Tetsuya; Arakawa, Yusuke; Mori, Hiroki; Hanaoka, Jun; Kanamoto, Mami; Sugimoto, Koji; Iwahashi, Shuichi; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito; Miyake, Hidenori; Shimada, Mitsuo
• Publication, Distribution, etc.: Springer nature
• Publication Date: 2012-06-16
• Publication Date (W3CDTF): 2012-06-16
• Alternative Title: 肝細胞癌の肝内再発における非癌部でのCD44発現の役割; CD44 expression in HCC
• Periodical title: International Journal of Clinical Oncology
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-24
• Date Granted (W3CDTF): 2014-03-24
• Dissertation Number: 甲第2669号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2669号
• Text Language Code: eng
• Subject Heading: hepatocellular carcinoma; CD44; prognostic factor; non tumor tissue
• Target Audience: 一般
• Note (General): Background: CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoproteininvolved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC).Methods: Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues.Results: In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two gourps. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (p<0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44.Conclusion: The CD44 expressions in the non-tumor tissues may predict HCC recurrence.
• DOI: info:doi/10.1007/s10147-012-0432-6; https://doi.org/info:doi/10.1007/s10147-012-0432-6
• Persistent ID (NDL): info:ndljp/pid/8949325; https://dl.ndl.go.jp/pid/8949325
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/106069
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp