Comparison between botulinum neurotoxin type A2 and type A1 by electrophysiological study in healthy individuals

• Material Type: 博士論文
• ISSN: 0041-0101
• Title: Comparison between botulinum neurotoxin type A2 and type A1 by electrophysiological study in healthy individuals
• Volume: 81
• Author/Editor: Mukai, Yohei; Shimatani, Yoshimitsu; Sako, Wataru; Asanuma, Kotaro; Nodera, Hiroyuki; Sakamoto, Takashi; Izumi, Yuishin; Kohda, Tomoko; Kozaki, Shunji; Kaji, Ryuji
• Author Heading: Mukai, Yohei; Shimatani, Yoshimitsu; Sako, Wataru; Asanuma, Kotaro; Nodera, Hiroyuki; Sakamoto, Takashi; Izumi, Yuishin; Kohda, Tomoko; Kozaki, Shunji; Kaji, Ryuji
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2014-02-01
• Publication Date (W3CDTF): 2014-02-01
• Alternative Title: 健常人におけるA1型とA2型のボツリヌス神経毒素の電気生理学的検査による比較
• Periodical title: Toxicon
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-19
• Date Granted (W3CDTF): 2014-03-19
• Dissertation Number: 甲第2743号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2743号
• Text Language Code: eng
• Subject Heading: Botulinum neurotoxin; A2NTX; EDB test; CMAP
• Target Audience: 一般
• Note (General): Botulinum neurotoxin type A1 (BoNTs/A1) and type B (BoNT/B) have been used for treating hyperactive muscle contractions. In the present study, we compared the effect of botulinum neurotoxin subtype A2 (6.5 mouse LD50 units A2 neurotoxin, A2NTX) and onabotulinumtoxinA (10 mouse LD50 units BoNT/A1 product) by measuring the compound muscle action potentials (CMAPs) before and after administration.In total, 8 healthy subjects were examined in the present study. A2NTX was injected into the extensor digitorum brevis (EDB) muscle, followed by onabotulinumtoxinA injection into the contralateral EDB muscle after 16 weeks. The CMAP amplitudes from the EDB, abductor hallucis (AH), and abductor digiti minimi pedis (ADM) muscles were measured after each BoNT injection on days 1, 3, 7, 14, 28, 56, 84, and 112 to assess the effect of the toxin. On day 14, both A2NTX and onabotulinumtoxinA produced an approximately 70% decline in EDB CMAP amplitude compared to the baseline values; significant reduction of the CMAP continued through day 112. The CMAP amplitudes from neighboring muscles (AH and ADM) remained intact throughout the study period, except for a slight but significant drop at day 28 after onabotulinumtoxinA injection compared to A2NTX. The current findings indicate that small doses (6.5 units and 10 units) of A2NTX and onabotulinumtoxinA have at least comparable onset and duration of action, although similar clinical effects were obtained with lower dose using A2NTX.
• DOI: info:doi/10.1016/j.toxicon.2013.12.012; https://doi.org/info:doi/10.1016/j.toxicon.2013.12.012
• Persistent ID (NDL): info:ndljp/pid/8949594; https://dl.ndl.go.jp/pid/8949594
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/106136
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp