Altered Activity of the Primary Visual Area during Gaze Processing in Individuals with High-Functioning Autistic Spectrum Disorder : A Magnetoencephalography Study

• Material Type: 博士論文
• Title: Altered Activity of the Primary Visual Area during Gaze Processing in Individuals with High-Functioning Autistic Spectrum Disorder : A Magnetoencephalography Study
• Author/Editor: Hasegawa, Naoya
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2014-03-24
• Publication Date (W3CDTF): 2014-03-24
• Alternative Title: Altered Activity of the Primary Visual Area during Gaze Processing in Individuals with High-Functioning Autistic Spectrum Disorder : A Magnetoencephalography Study; 高機能自閉症者の健常者とは異なる視線認知時における一次視覚野の活動：脳磁図による研究
• Degree grantor/type: 新潟大学
• Date Granted: 2014-03-24
• Date Granted (W3CDTF): 2014-03-24
• Dissertation Number: 甲第3859号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3859号
• Text Language Code: eng
• Subject Heading: Autistic spectrum disorder; Magnetoencephalography; Gaze processing; Social cognition; Minimum current estimates; Primary visual area
• Note (General): Background: Individuals with autistic spectrum disorder (ASD) demonstrate an impaired ability to infer the mental states of others from their gaze. Thus, investigating the relationship between ASD and eye gaze processing is crucial for understanding the neural basis of social impairments seen in individuals with ASD. In addition, characteristics of ASD are observed in more comprehensive visual perception tasks. These visual characteristics of ASD have been well-explained in terms of the atypical relationship between high and low-level gaze processing in ASD. Method: We studied neural activity during gaze processing in individuals with ASD using magnetoencephalography, with a focus on the relationship between high and low-level gaze processing both temporally and spatially. Minimum current estimate analysis was applied to perform source analysis of magnetic responses to gaze stimuli. Results: The source analysis showed that later activity in the primary visual area (V1) was affected by gaze direction only in the ASD group. Conversely, the right posterior superior temporal sulcus, which is a brain region that processes gaze as a social signal, in the typically developed group showed a tendency toward greater activation during direct compared with averted gaze processing. Conclusion: These results suggest that later activity in V1 relating to gaze processing is altered or possibly enhanced in high-functioning individuals with ASD, which may underpin the social cognitive impairments in these individuals.; 学位の種類: 博士（医学）. 報告番号: 甲第3859号. 学位記番号: 新大院博（医）甲第599号. 学位授与年月日: 平成26年3月24日; Neuropsychobiology. 2013, 68(3), 181-188; 新大院博（医）甲第599号; 元資料の権利情報 : Copyright (C) 2013 S. Karger AG; 開始ページ : 1; 終了ページ : 18
• DOI: info:doi/10.1159/000354866; https://doi.org/info:doi/10.1159/000354866
• Persistent ID (NDL): info:ndljp/pid/8949859; https://dl.ndl.go.jp/pid/8949859
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/27350
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp