Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model.

• Material Type: 博士論文
• ISSN: 1386-6346
• Title: Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model.
• Volume: 43 11
• Author/Editor: Aihara, Yosuke; Yoshiji, Hitoshi; Noguchi, Ryuichi; Kaji, Kosuke; Namisaki, Tadashi; Shirai, Yusaku; Douhara, Akitoshi; Moriya, Kei; Kawaratani, Hideto; Fukui, Hiroshi
• Author Heading: Aihara, Yosuke; Yoshiji, Hitoshi; Noguchi, Ryuichi; Kaji, Kosuke; Namisaki, Tadashi; Shirai, Yusaku; Douhara, Akitoshi; Moriya, Kei; Kawaratani, Hideto; Fukui, Hiroshi
• Publication, Distribution, etc.: Wiley / The Japan Society of Hepatology
• Publication Date: 2013-11; 43 11
• Publication Date (W3CDTF): 2013-11
• Alternative Title: 直接的レニン阻害薬であるアリスキレンはラットモデルにおいて非アルコール性脂肪肝炎の進行を抑制する
• Periodical title: Hepatology research
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第612号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第612号
• Text Language Code: eng
• Subject Heading: angiotensin-II; hepatocarcinogenesis; liver fibrosis; non-alcoholic; steatohepatitis; renin
• Target Audience: 一般
• Note (General): type:Thesis; AIM: Renin is a rate-limiting enzyme of the renin-angiotensin system (RAS), andseveral reports have shown that renin plays an important role in severalpathological processes. Although RAS is known to play a pivotal role in theprogression of non-alcoholic steatohepatitis (NASH), the role of renin is stillobscure. The aim of the current study was to examine the effect of the clinicallyused direct renin inhibitor (DRI), aliskiren, on the progression of NASH in a ratmodel.METHODS: The effects of DRI on the choline-deficient L-amino acid-defined (CDAA)diet-induced rat NASH model was examined in conjunction with the activatedhepatic stellate cells (Ac-HSC) and neovascularization, both of which are knownto play important roles in liver fibrosis development and hepatocarcinogenesis,respectively.RESULTS: DRI exerted a marked inhibitory effect against liver fibrosisdevelopment and glutathione-S-transferase placental form (GST-P) positivepreneoplastic lesions along with suppression of the Ac-HSC and neovascularizationin a dose-dependent manner. DRI also inhibited the hepatic expressions oftransforming growth factor-beta 1 (TGF-beta 1), angiotensin-II (AT-II) andvascular endothelial growth factor (VEGF). These results indicated that reninplayed a pivotal role in the liver fibrosis development and hepatocarcinogenesisof NASH.CONCLUSION: Because DRI is already widely used in the clinical practice withsafety, this drug may represent a potential new strategy against the progressionof NASH in the future.; 博士（医学）・甲612号・平成26年3月17日; identifier:Hepatology research Vol.43 No.11 p.1241-1250; identifier:13866346; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2697; identifier:Hepatology research, 43(11): 1241-1250
• DOI: info:doi/10.1111/hepr.12081; https://doi.org/info:doi/10.1111/hepr.12081
• Persistent ID (NDL): info:ndljp/pid/8950064; https://dl.ndl.go.jp/pid/8950064
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2697
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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