ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.

• Material Type: 博士論文
• ISSN: 1386-6346
• Title: ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.
• Volume: 42 5
• Author/Editor: Takaya, Hiroaki; Uemura, Masahito; Fujimura, Yoshihiro; Matsumoto, Masanori; Matsuyama, Tomomi; Kato, Seiji; Morioka, Chie; Ishizashi, Hiromichi; Hori, Yuji; Fujimoto, Masao; Tsujimoto, Tatsuhiro; Kawaratani, Hideto; Toyohara, Masahisa; Kurumatani, Norio; Fukui, Hiroshi
• Author Heading: Takaya, Hiroaki; Uemura, Masahito; Fujimura, Yoshihiro; Matsumoto, Masanori; Matsuyama, Tomomi; Kato, Seiji; Morioka, Chie; Ishizashi, Hiromichi; Hori, Yuji; Fujimoto, Masao; Tsujimoto, Tatsuhiro; Kawaratani, Hideto; Toyohara, Masahisa; Kurumatani, Norio; Fukui, Hiroshi
• Publication, Distribution, etc.: Wiley / The Japan Society of Hepatology
• Publication Date: 2012-05; 42 5
• Publication Date (W3CDTF): 2012-05
• Alternative Title: 血漿ADAMTSは肝硬変患者の予後をChild-PughスコアやMELDスコアと同様に生存率を予測できる可能性がある
• Periodical title: Hepatology research
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第613号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第613号
• Text Language Code: eng
• Subject Heading: ADAMTS13 activity; Child-Turcotte-Pugh score; liver cirrhosis; Model for End-Stage Liver Disease score; prognosis
• Target Audience: 一般
• Note (General): type:Thesis; Aim: Decreased plasma ADAMTS13 activity (ADAMTS13:AC) results in accumulation of unusually large von Willebrand factor multimers and platelet thrombi formation. Our aim was to evaluate whether ADAMTS13:AC is a prognostic marker in patients with liver cirrhosis. Methods: Plasma ADAMTS13:AC and its related parameters were examined in 108 cirrhotic patients. Results: ADAMTS13:AC decreased as the severity of liver disease increased (means: controls 100%, Child A-cirrhotics 79%, Child B-cirrhotics 63%, and Child C-cirrhotics 31%). ADAMTS13:AC markedly decreased in the cirrhotics with hepatorenal syndrome, refractory ascites and hepatic encephalopathy. The cumulative survival time was the shortest (median: 4.5 months) in the cirrhotics with severe to moderate ADAMTS13:AC deficiency (<3-25%), followed by those with mild ADAMTS13:AC deficiency (25-50%), and was the longest in those with normal activity (>50%). In contrast, based on the Child-Turcotte-Pugh (CTP) score, Child C-cirrhotics had the worst survival, but the survival probabilities did not differ between Child A and B cirrhotics. Based on the Model for End-Stage Liver Disease (MELD) score, the survival was the worst for the cirrhotics in the fourth quartile, but it was not different among cirrhotics in the first three quartiles. Cox proportional-hazards regression analysis showed that ADAMTS13:AC and serum albumin were independent factors affecting the survival. Conclusions: ADAMTS13:AC concomitantly decreases as the functional liver capacity decreases. This activity may be a useful prognostic marker that is equal or superior to the CTP score and the MELD score to predict not only the short-term prognosis but also the long-term survival of the cirrhotic patients.; 博士（医学）・甲613号・平成26年3月17日; identifier:Hepatology research Vol.42 No.5 p.459-472; identifier:13866346; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2698; identifier:Hepatology research, 42(5): 459-472
• DOI: info:doi/10.1111/j.1872-034X.2011.00950.x; https://doi.org/info:doi/10.1111/j.1872-034X.2011.00950.x
• Persistent ID (NDL): info:ndljp/pid/8950065; https://dl.ndl.go.jp/pid/8950065
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2698
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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