NHE-1 blockade reversed changes in calcium transient in myocardial slices from isoproterenol-induced hypertrophied rat left ventricle.

• Material Type: 博士論文
• ISSN: 0006-291X
• Title: NHE-1 blockade reversed changes in calcium transient in myocardial slices from isoproterenol-induced hypertrophied rat left ventricle.
• Volume: 419 2
• Author/Editor: Hattori, Hiroshi; Takeshita, Daisuke; Takeuchi, Ayako; Kim, Bongju; Shibata, Munetaka; Matsuoka, Satoshi; Obata, Koji; Mitsuyama, Shinichi; Zhang, Guo-Xing; Takaki, Miyako
• Author Heading: Hattori, Hiroshi; Takeshita, Daisuke; Takeuchi, Ayako; Kim, Bongju; Shibata, Munetaka; Matsuoka, Satoshi; Obata, Koji; Mitsuyama, Shinichi; Zhang, Guo-Xing; Takaki, Miyako
• Publication, Distribution, etc.: Academic Press / Elsevier
• Publication Date: 2012-03-09; 419 2
• Publication Date (W3CDTF): 2012-03-09
• Alternative Title: イソプロテレノール誘導肥大心においてNHE-1阻害薬は、ラット左心室の筋スライスのCa2+トランジェントを正常化する
• Periodical title: Biochemical and biophysical research communications
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第618号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第618号
• Text Language Code: eng
• Subject Heading: Calcium transient; Cardiac hypertrophy; Excitation–contraction coupling; Myocardial slice; Na+/H+ exchanger-1
• Target Audience: 一般
• Note (General): type:Thesis; We previously reported that left ventricular (LV) slices from isoproterenol (ISO)-induced hypertrophied rat hearts showed an increase of energy expenditure due to remodeling of Ca2+ handling in excitation–contraction coupling, i.e., suppressed SERCA2a activity and enhanced Na+/Ca2+exchanger-1 (NCX-1) activity. Na+/H+ exchanger-1 (NHE-1) inhibitor (NHEI) has been demonstrated to exert beneficial effects in the development of cardiac remodeling. We hypothesized that a novel NHE-1 selective inhibitor, BIIB723 prevents remodeling of Ca2+ handling in LV slices of ISO-induced hypertrophied rat hearts mediated by inhibiting NCX-1 activity. The significant shortening in duration of multi-cellular Ca2+ transient in ISO group was normalized in ISO + BIIB723 group. The significant increase in amplitude of multi-cellular Ca2+ waves (CaW) generated at high [Ca2+]o of LV slices in ISO group was also normalized in ISO + BIIB723 group. However, the enhanced NCX-1 activity was not antagonized by BIIB723. We recently reported that ISO-induced down-regulation of a Ca2+ handling protein, SERCA2a, was normalized by BIIB723. Therefore, it seems likely that BIIB723 normalized shortened multi-cellular Ca2+ transient duration and increased CaW amplitude in LV slices mediated via normalization of SERCA2a activity. Furthermore, the results presented here suggest the multi-cellular Ca2+ transient duration and CaW amplitude in LV slices might be better indices reflecting SERCA2a activity than SERCA2a protein expression level.; 博士（医学）・甲618号・平成26年3月17日; identifier:Biochemical and biophysical research communications Vol.419 No.2 p.431-435; identifier:0006291X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2703; identifier:Biochemical and biophysical research communications, 419(2): 431-435
• DOI: info:doi/10.1016/j.bbrc.2012.02.041; https://doi.org/info:doi/10.1016/j.bbrc.2012.02.041
• Persistent ID (NDL): info:ndljp/pid/8950067; https://dl.ndl.go.jp/pid/8950067
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2703
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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