Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats.

• Material Type: 博士論文
• ISSN: 0022-2828
• Title: Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats.
• Volume: 59
• Author/Editor: Mitsuyama, Shinichi; Takeshita, Daisuke; Obata, Koji; Zhang, Guo-Xing; Takaki, Miyako
• Author Heading: Mitsuyama, Shinichi; Takeshita, Daisuke; Obata, Koji; Zhang, Guo-Xing; Takaki, Miyako
• Publication, Distribution, etc.: Academic Press / Elsevier
• Publication Date: 2013-06; 59
• Publication Date (W3CDTF): 2013-06
• Alternative Title: SERCA2a過剰発現ラットにおけるイソプロテレノール持続投与誘導肥大心の左室力学的エネルギー学的性質の変化
• Periodical title: Journal of molecular and cellular cardiology
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第619号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第619号
• Text Language Code: eng
• Subject Heading: Heart failure; Ca2 + handling; Oxygen consumption; Excitation–contraction coupling
• Target Audience: 一般
• Note (General): type:Thesis; Overexpression of cardiac sarcoplasmic reticulum Ca2 +-ATPase (SERCA2a) has been suggested as a strategic intervention for cardiac failure. However, its benefit in wild-type (WT) rats with normal SERCA2a levels seems to be small. To investigate whether it would be beneficial in a cardiac failure model with down-regulated SERCA2a levels, we made a cardiac hypertrophy model using isoproterenol infusion (1.2 mg kg− 1 day− 1 for 1 or 4 weeks; TG-ISO1w and TG-ISO4w, respectively) in SERCA2a transgenic (TG) rats and compared these rats with littermate WT rats that underwent the same treatments (WT-ISO1w and WT-ISO4w). We analyzed the left ventricular (LV) mechanoenergetics in the excised heart using our original cross-circulation system. The downward shift of curvilinear LV end-systolic pressure–volume relations (ESPVRs) observed in WT-ISO4w rats was abolished in TG-ISO4w rats. The slope and VO2 intercept of the VO2 (myocardial oxygen consumption per beat)–PVA (systolic pressure–volume area: total mechanical energy per beat) linear relation did not differ in any of the groups. The most important finding was a significantly smaller O2 cost of LV contractility in the TG-ISO4w group, which means that less O2 is needed to exert the same LV contractility, compared with the other groups. The increased ratio of SERCA2a/phospholamban returned to the level of the WT-control group only in the TG-ISO4w group. Longer-term up-regulation of mitochondrial transcription factor A for genes of mitochondrial enzymes producing ATP was observed in TG rats. In conclusion, longer-term overexpression of SERCA2a will be beneficial in the present cardiac failure model with down-regulated SERCA2a levels.; 博士（医学）・甲619号・平成26年3月17日; identifier:Journal of molecular and cellular cardiology Vol.59 p.95-106; identifier:00222828; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2704; identifier:Journal of molecular and cellular cardiology, 59: 95-106
• DOI: info:doi/10.1016/j.yjmcc.2013.02.012; https://doi.org/info:doi/10.1016/j.yjmcc.2013.02.012
• Persistent ID (NDL): info:ndljp/pid/8950068; https://dl.ndl.go.jp/pid/8950068
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2704
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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