Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions. 1

• Material Type: 博士論文
• ISSN: 1880-6546
• Title: Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions.
• Volume: 64 1
• Author/Editor: Yamada, Atsushi; Torimoto, Kazumasa; Obata, Koji; Hirayama, Akihide; Fujimoto, Kiyohide; Takaki, Miyako
• Author Heading: Yamada, Atsushi; Torimoto, Kazumasa; Obata, Koji; Hirayama, Akihide; Fujimoto, Kiyohide; Takaki, Miyako
• Publication, Distribution, etc.: Physiological Society of Japan / Springer Japan
• Publication Date: 2014-01; 64 1
• Publication Date (W3CDTF): 2014-01
• Alternative Title: SERCA2aの持続的過剰発現は、生理的条件下では膀胱機能に影響を及ぼすが、膀胱出口部閉塞亜急性期の病的条件下では膀胱機能に影響しない
• Periodical title: The journal of physiological science
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-05-28
• Date Granted (W3CDTF): 2014-05-28
• Dissertation Number: 甲第623号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第623号
• Text Language Code: eng
• Subject Heading: Rat bladder; SERCA2 overexpression; Cystometry; Outlet obstruction; Hypertrophy
• Target Audience: 一般
• Note (General): type:Thesis; A functional impairment of the bladder and heart in a decompensated state caused by a pressure overload is accompanied by a decrease in the sarcoplasmic reticulum Ca2+-ATPase (SERCA2). The beneficial effects of SERCA2 overexpression in preserving cardiac functions have been previously reported. The aim of the present study was to investigate the effects of overexpressed SERCA2 on bladder functions under physiological and pathological conditions using partial bladder outlet obstruction (BOO) in SERCA2a transgenic Wistar rats (TG). Bladder cystometry and western blot analysis were performed using the wild-type Wistar rats (WT), TG, and BOO models (WTBOO and TGBOO). Persistent overexpression of SERCA2 induces reduced bladder compliance without hypertrophy in TG. BOO induces reduced bladder compliance and hypertrophy in WT and TG in the sub-acute phase, but persistent overexpression of SERCA2a in TG does not aggravate the bladder compliance and hypertrophy. In conclusion, SERCA2a overexpression affects bladder functions under physiological conditions, but not in BOO-induced sub-acute pathological conditions.; 博士（医学）・甲第623号・平成26年5月28日; identifier:The journal of physiological science Vol.64 No.1 p.21-30; identifier:18806546; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2718; identifier:The journal of physiological science, 64(1): 21-30
• DOI: info:doi/10.1007/s12576-013-0286-3; https://doi.org/info:doi/10.1007/s12576-013-0286-3
• Persistent ID (NDL): info:ndljp/pid/8950890; https://dl.ndl.go.jp/pid/8950890
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2718
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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