Using Computational Fluid Dynamics Analysis to Characterize Local Hemodynamic Features of Middle Cerebral Artery Aneurysm Rupture Points

• Material Type: 博士論文
• Title: Using Computational Fluid Dynamics Analysis to Characterize Local Hemodynamic Features of Middle Cerebral Artery Aneurysm Rupture Points
• Author/Editor: Fukazawa, Keiji
• Author Heading: Fukazawa, Keiji
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2013-01-01
• Publication Date (W3CDTF): 2013-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2013-07-17
• Date Granted (W3CDTF): 2013-07-17
• Dissertation Number: 甲医学第1634号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1634号
• Text Language Code: eng
• Alias of Author: フカザワ, ケイジ; 深澤, 恵児
• Subject Heading: Computational fluid dynamics; Local hemodynamics; Rupture point; Ruptured cerebral aneurysm; Wall shear stress
• Target Audience: 一般
• Note (General): application/pdf; OBJECTIVE: Although rupture of cerebral aneurysms typically occurs at the fragile wall at the apex or pole, some aneurysms rupture through the body or the neck. The purpose of this study was to clarify the association between aneurysm rupture points and hemodynamic features through the use of computational fluid dynamics (CFD) analysis. METHODS: Twelve ruptured middle cerebral artery bifurcation aneurysms were analyzed by 3-dimensional computed tomographic angiography and CFD. Rupture points were evaluated on intraoperative videos by 3 independent neurosurgeons. Wall shear stress (WSS) was calculated at the rupture point, aneurysm dome, and parent artery. Intra-aneurysmal flow patterns were evaluated with cross-sectional velocity vector planes that included the rupture points. RESULTS: The mean WSS at the rupture point (0.29 Pa) was significantly lower than that at the dome (2.27 Pa) and the parent artery (8.19 Pa) (P < .01). All rupture points were located within the area of WSS ≤ 11.2% of the WSS at the parent artery. WSS at the rupture point was correlated with the minimum WSS at the dome (r = 0.64, P < .05), but not with aneurysm size (r = 0.26) or the aspect ratio (r = 0.16). Flow patterns revealed that all rupture points were located in lower-velocity area, which was associated with complex flow patterns and/or deviating necks. CONCLUSIONS: This study highlights the relationship between the local hemodynamic features and the rupture points observed during the microsurgical clipping. CFD may determine a rupture point of aneurysms using the feature of markedly low WSS.; 本文 / Department of Neurosurgery, NHO Mie Chuo Medical Center, Mie, Japan; 7p; http://www.sciencedirect.com/science/article/pii/S1878875013002775
• DOI: info:doi/10.1016/j.wneu.2013.02.012; https://doi.org/info:doi/10.1016/j.wneu.2013.02.012
• Persistent ID (NDL): info:ndljp/pid/8951816; https://dl.ndl.go.jp/pid/8951816
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://www.sciencedirect.com/science/article/pii/S1878875013002775
• Periodical Title (URI): http://hdl.handle.net/10076/13988; https://mie-u.repo.nii.ac.jp/records/7811
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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