Association of p62/SQSTM1 excess and oral carcinogenesis.

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Association of p62/SQSTM1 excess and oral carcinogenesis.
• Volume: 8 9
• Author/Editor: INUI, Takuma
• Author Heading: INUI, Takuma
• Publication, Distribution, etc.: PLoS one
• Publication Date: 2013-09-24
• Publication Date (W3CDTF): 2013-09-24
• Periodical title: PLoS one
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2014-03-10
• Date Granted (W3CDTF): 2014-03-10
• Dissertation Number: 甲第692号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第692号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): p62/SQSTM1 (sequestosome1) has never been evaluated in oral epithelium. In order to clarify the role of p62/SQSTM1 in carcinogenesis in oral epithelium, both p62/SQSTM1 and Nrf2 were immunohistochemically evaluated in 54 carcinomas and 14 low grade dysplasias. p62/SQSTM1 knockdowns were also designed in oral cancer cells, and we analyzed the Nrf2 pathway, GSH contents and ROS accumulation. The association between p62/SQSTM1 excess and prognosis was addressed in a clinical cohort of oral carcinoma cases. p62/SQSTM1 excess was more obvious in carcinomas, but Nrf2 was abundant in almost all samples of the oral epithelium. In oral carcinoma cells, p62/SQSTM1 knockdown did not affect the Nrf2-Keap1 pathway but did significantly reduce GSH content with subsequent ROS accumulation, and caused cell growth inhibition in the irradiated condition. Finally, p62/SQSTM1 excess was associated with poor prognosis in a clinical cohort. In oral epithelial carcinogenesis, p62/SQSTM1 excess played a role in GSH induction rather than Nrf2 accumulation, and may cause resistance to cytotoxic stresses such as radiation or chemotherapy. Immunohistochemical evaluation of p62/SQSTM1 may be a potential significant marker to identify early carcinogenesis, chemo-radiotherapeutic resistance or poor prognosis of oral squamous cell carcinomas.; Thesis or Dissertation; 平成25年度; 10.1371/journal.pone.0074398
• DOI: info:doi/10.1371/journal.pone.0074398; https://doi.org/info:doi/10.1371/journal.pone.0074398
• Persistent ID (NDL): info:ndljp/pid/8952037; https://dl.ndl.go.jp/pid/8952037
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/7354; https://shiga-med.repo.nii.ac.jp/records/2091
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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