Mechanisms underlying cancer progression caused by ezrin overexpression in tongue squamous cell carcinoma.

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Mechanisms underlying cancer progression caused by ezrin overexpression in tongue squamous cell carcinoma.
• Volume: 8 1
• Author/Editor: SAITO, Shota
• Author Heading: SAITO, Shota
• Publication, Distribution, etc.: PLoS one
• Publication Date: 2013-01-24
• Publication Date (W3CDTF): 2013-01-24
• Periodical title: PLoS one
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2014-03-10
• Date Granted (W3CDTF): 2014-03-10
• Dissertation Number: 甲第698号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第698号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Background:Ezrin is a member of the ezrin, radixin, and moesin family that provides a functional link between the plasma membrane and the cortical actin cytoskeleton. A correlation between ezrin overexpression and aggressive cancer behavior has been recently reported in various tumor types. However, its roles in the mechanisms underlying progression of tongue squamous cell carcinoma (SCC) are unclear.; Method:We used human tongue SCC and noncancerous tissue microarrays to immunohistochemically analyze the ezrin expression level and its relationship with proliferative activity. The human tongue SCC cell line HSC-3 was used to determine the effects of ezrin RNA interference (RNAi) on cancer cells during MTT; wound healing and invasion assays; immunofluorescence of the actin cytoskeleton; and western blotting of E-cadherin, N-cadherin, β-catenin, and the active and total RhoA/Rac1/cdc42.; Results:Ezrin was overexpressed in 46.4% of the tumors examined in human tongue SCC tissue microarrays. Ezrin expression was correlated with the Ki-67 index. Ezrin depletion by RNAi in the HSC-3 cells significantly reduced cell proliferation, migration, and invasiveness and disturbed actin reorganization during podia formation. Its effects on RhoA/Rac1/cdc42 expression were not significant, whereas it enhanced E-cadherin and β-catenin expression and decreased N-cadherin expression.; Conclusions:Ezrin is often overexpressed in primary tongue SCCs and may have an important role in their growth, migration, and invasiveness possibly via its relationship with the E-cadherin/β-catenin complex and the cadherin switch. Thus, ezrin could be a therapeutic target in tongue SCC.; Thesis or Dissertation; 平成25年度; 10.1371/journal.pone.0054881
• DOI: info:doi/10.1371/journal.pone.0054881; https://doi.org/info:doi/10.1371/journal.pone.0054881
• Persistent ID (NDL): info:ndljp/pid/8952038; https://dl.ndl.go.jp/pid/8952038
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/7355; https://shiga-med.repo.nii.ac.jp/records/2813
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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