Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.

• Material Type: 博士論文
• ISSN: 1932-6203
• Title: Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
• Volume: 8 12
• Author/Editor: NAKAYAMA, Misako
• Author Heading: NAKAYAMA, Misako
• Publication, Distribution, etc.: PLoS one
• Publication Date: 2013-12-23
• Publication Date (W3CDTF): 2013-12-23
• Periodical title: PLoS one
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2014-03-10
• Date Granted (W3CDTF): 2014-03-10
• Dissertation Number: 甲第708号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第708号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against a broad spectrum of H5N1 viruses is preferable for pandemic preparedness. We established a second H5N1 vaccine candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), in our virus library and examined the efficacy of inactivated whole particles of this strain against two clades of H5N1 HPAIV strains that caused severe morbidity in cynomolgus macaques. Virus propagation in vaccinated macaques infected with either of the H5N1 HPAIV strains was prevented compared with that in unvaccinated macaques. This vaccine also prevented propagation of a pandemic (H1N1) 2009 virus in macaques. In the vaccinated macaques, neutralization activity, which was mainly shown by anti-hemagglutinin antibody, against H5N1 HPAIVs in plasma was detected, but that against H1N1 virus was not detected. However, neuraminidase inhibition activity in plasma and T-lymphocyte responses in lymph nodes against H1N1 virus were detected. Therefore, cross-clade and heterosubtypic protective immunity in macaques consisted of humoral and cellular immunity induced by vaccination with Vac-3.; Thesis or Dissertation; 平成25年度; 10.1371/journal.pone.0082740
• DOI: info:doi/10.1371/journal.pone.0082740; https://doi.org/info:doi/10.1371/journal.pone.0082740
• Persistent ID (NDL): info:ndljp/pid/8952040; https://dl.ndl.go.jp/pid/8952040
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/7357; https://shiga-med.repo.nii.ac.jp/records/2817
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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