Distinct localization of peripheral and central types of choline acetyltransferase in the rat cochlea.

• Material Type: 博士論文
• ISSN: 0044-5991
• Title: Distinct localization of peripheral and central types of choline acetyltransferase in the rat cochlea.
• Volume: 46 5
• Author/Editor: KITANISHI, Tsuyoshi
• Author Heading: KITANISHI, Tsuyoshi
• Publication, Distribution, etc.: Japan Society of Histochemistry and Cytochemistry
• Publication Date: 2013-10-30
• Publication Date (W3CDTF): 2013-10-30
• Periodical title: Acta Histochemica et Cytochemica
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2014-03-10
• Date Granted (W3CDTF): 2014-03-10
• Dissertation Number: 乙第403号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第403号
• Text Language Code: eng
• Subject Heading: acetylcholine; cholinergic neurons; choline acetyltransferase; cochlear nervous system; spiral ganglion
• Target Audience: 一般
• Note (General): We previously discovered a splice variant of choline acetyltransferase (ChAT) mRNA, and designated the variant protein pChAT because of its preferential expression in peripheral neuronal structures. In this study, we examined the immunohistochemical localization of pChAT in rat cochlea and compared the distribution pattern to those of common ChAT (cChAT) and acetylcholinesterase. Some neuronal cell bodies and fibers in the spiral ganglia showed immunoreactivity for pChAT, predominantly the small spiral ganglion cells, indicating outer hair cell type II neurons. In contrast, cChAT- and acetylcholinesterase-positive structures were localized to fibers and not apparent in ganglion cells. After ablation of the cochlear nuclei, many pChAT-positive cochlear nerve fibers became clearly visible, whereas fibers immunopositive for cChAT and acetylcholine esterase disappeared. These results suggested that pChAT and cChAT are localized in different systems of the rat cochlea; pChAT in the afferent and cChAT in the efferent structures.; Thesis or Dissertation; 平成25年度
• DOI: info:doi/10.1267/ahc.13021; https://doi.org/info:doi/10.1267/ahc.13021
• Persistent ID (NDL): info:ndljp/pid/8952228; https://dl.ndl.go.jp/pid/8952228
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/7512; https://shiga-med.repo.nii.ac.jp/records/1368
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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