Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly 8 1

The cover of this title could differ from library to library.

Available in National Diet Library

Find on the publisher's website

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

DOI[info:doi/10.1016/j.celrep.2014.05.043]to the data of the same series

Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly 1

Persistent ID (NDL): info:ndljp/pid/8952372

Material type: 博士論文

Author: Murota, Yukikoほか

Publisher: Elsevier

Publication date: 2014-06-19

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 徳島大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation ...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
ISSN: 2211-1247
Title: Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly
Volume: 8 1
Author/Editor: Murota, Yukiko
Ishizu, Hirotsugu
Nakagawa, Shinichi
Iwasaki, Yuka W.
Shibata, Shinsuke
Kamatani, Miharu K.
Saito, Kuniaki
Okano, Hideyuki
Shiomi, Haruhiko
Siomi, Mikiko C.
Author Heading: Murota, Yukiko
Ishizu, Hirotsugu
Nakagawa, Shinichi
Iwasaki, Yuka W.
Shibata, Shinsuke
Kamatani, Miharu K.
Saito, Kuniaki
Okano, Hideyuki
Shiomi, Haruhiko
Siomi, Mikiko C.
Publication, Distribution, etc.: Elsevier
Publication Date: 2014-06-19
Publication Date (W3CDTF): 2014-06-19
Alternative Title: YbはpiRNA前駆体とpiRNA生合成因子を核周辺部位に形成される顆粒体に局在させることによってpiRISC形成を促進する
Periodical title: Cell Reports
Degree grantor/type: 徳島大学
Date Granted: 2014-10-23
Date Granted (W3CDTF): 2014-10-23
Dissertation Number: 甲第2779号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第2779号
Text Language Code: eng
Subject Heading: piRNA
Piwi
flamenco
Yb body
Drosophila
Target Audience: 一般
Note (General): PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) localize to perinuclear foci adjacent to Yb bodies, termed Flam bodies. RNAi-based screening of piRNA factors revealed that Flam body formation depends on Yb, the core component of Yb bodies, while Piwi and another Yb body component, Armitage, are dispensable for formation. Abolishing the RNA-binding activity of Yb disrupts both Flam bodies and Yb bodies. Yb directly binds flam, but not transcripts from neighboring protein-coding genes. Thus, Yb integrates piRNA intermediates and piRNA processing factors selectively into Flam bodies and Yb bodies, respectively. We suggest that Yb is a key upstream factor in the cytoplasmic phase of the piRNA pathway in ovarian somatic cells.
DOI: info:doi/10.1016/j.celrep.2014.05.043
https://doi.org/info:doi/10.1016/j.celrep.2014.05.043
Persistent ID (NDL): info:ndljp/pid/8952372
https://dl.ndl.go.jp/pid/8952372
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Available (W3CDTF): 2015-03-03
Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/106315
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp