RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer

• Material Type: 博士論文
• Title: RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer
• Author/Editor: Oshita, Hideto
• Publication Date: 2013-09-05
• Publication Date (W3CDTF): 2013-09-05
• Alternative Title: RASEFは肺癌の新たな診断マーカー及び治療標的である
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2013-09-05
• Date Granted (W3CDTF): 2013-09-05
• Dissertation Number: 甲第6214号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第6214号
• Text Language Code: eng
• Subject Heading: oncogenes; cancer antigen; biomarker; therapeutic target; lungcancer
• NDC: 490
• Note (General): Genome-wide gene expression profile analyses revealed that Ras and EF-hand domain containing (RASEF) was significantly transactivated in the majority of lung cancers. Transient expression of RASEF promoted cell growth, whereas transfection of siRNA for RASEF to lung cancer cells reduced its expression and resulted in growth suppression of the cancer cells. Immunohistochemical staining using tumor tissue microarrays consisting of 341 archived non-small cell lung cancers revealed the association of strong RASEF positivity with poor prognosis (P = 0.0034 by multivariate analysis). RASEF could bind to extracellular signal-regulated kinase (ERK) 1/2 and appeared to enhance the ERK1/2 signaling. In addition, inhibition of interaction between RASEF and ERK1/2 using cell-permeable peptide that corresponded to the ERK1/2-interacting site of RASEF protein, suppressed growth of lung cancer cells. RASEF may play important roles in lung carcinogenesis, and could be useful as a prognostic biomarker and a target for the development of new molecular therapies.; 元資料の権利情報 : Copyright(c) by Author
• Persistent ID (NDL): info:ndljp/pid/8952570; https://dl.ndl.go.jp/pid/8952570
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-21
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036269
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集