Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates

• Material Type: 博士論文
• Title: Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates
• Author/Editor: Tazawa, Hirofumi
• Publication Date: 2013-11-28
• Publication Date (W3CDTF): 2013-11-28
• Alternative Title: 多型性のないT細胞レセプターとCD1d分子のシグナル遮断は血液型A型抗原に対する抗体産生を特異的に抑制する
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2013-11-28
• Date Granted (W3CDTF): 2013-11-28
• Dissertation Number: 甲第6271号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第6271号
• Text Language Code: eng
• NDC: 490
• Note (General): Previously, we detected B cells expressing receptors for blood group A carbohydrates in the CD11b+CD5+ B-1a subpopulation in mice, similar to that in blood group O or B in humans. In the present study, we demonstrated that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells. After immunization of wild-type (WT) mice with human blood group A red blood cells (A-RBCs), interleukin (IL)-5 exclusively and transiently increased, and the anti-A Abs were elevated in sera; however, those were not observed at all in CD1d-/- mice, which lack NKT cells. Administration of anti-mouse CD1d blocking mAb prior to the immunization abolished IL-5 production by NKT cells and anti-A Ab production in WT mice. Administration of anti-IL-5 neutralizing mAb also diminished anti-A Ab production in WT mice, suggesting that IL-5 secreted from NKT cells critically regulates anti-A Ab production by B-1a cells. In NOD/SCID/γc null mice, into which peripheral blood mononuclear cells from type O human volunteers were engrafted, administration of anti-human CD1d mAb prior to the A-RBC immunization completely inhibited anti-A Ab production. Thus, anti-CD1d treatment might constitute a novel approach that could help in evading Ab-mediated rejection in ABOincompatible transplants.; 元資料の権利情報 : Copyright(c) by Author
• Persistent ID (NDL): info:ndljp/pid/8952579; https://dl.ndl.go.jp/pid/8952579
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-21
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036279
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集