Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study

• Material Type: 博士論文
• Title: Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study
• Author/Editor: 平野, 雅俊
• Author Heading: 平野, 雅俊
• Publication Date: 2014-01-23
• Publication Date (W3CDTF): 2014-01-23
• Alternative Title: 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより
• Degree grantor/type: 広島大学
• Date Granted: 2014-01-23
• Date Granted (W3CDTF): 2014-01-23
• Dissertation Number: 甲第6278号
• Degree Type: 博士(医学); Philosophy in Medical Science
• Conferring No. (Dissertation): 甲第6278号
• Text Language Code: eng
• Alias of Author: Hirano, Masatoshi
• Subject Heading: High-density lipoprotein cholesterol; Type 2 diabetes; Westernized lifestyle
• NDC: 490
• Target Audience: 一般
• Note (General): Aims/Introduction: A low level of high-density lipoprotein cholesterol (HDLC) is a common feature of metabolic syndrome. We have reported that Japanese-Americans who share a virtually identical genetic makeup with native Japanese, but who have lived Westernized lifestyles for decades, have lower HDLC levels and a high prevalence of type 2 diabetes compared with native Japanese. However, the impact of low HDLC level on type 2 diabetes is unclear. The aims of the present study were to evaluate whether serum HDLC level was associated with development of type 2 diabetes and if the effect might be modified by lifestyle. Materials and Methods: We examined 1,133 non-diabetic Japanese-Americans and 1,072 non-diabetic Japanese, who underwent the 75-g oral glucose tolerance test (OGTT) and were followed for an average of 8.8 and 7.0 years, respectively. We analyzed whether serum HDLC level is a risk factor for development of type 2 diabetes based on the Cox proportional hazards model. Results: After adjustment for age and sex, hazard ratios for development of type 2 diabetes per unit of serum HDLC level (mmol/L) were 0.292 (95% confidence interval [CI] 0.186-0.458, P < 0.0001) among Japanese-Americans and 0.551 (95% CI 0.375-0.88, P = 0.0023) among native Japanese. Comparable hazard ratios after further adjustment for category of OGTT and body mass index were 0.981 (95% CI 0.970-0.993, P = 0.0018) and 0.991 (95% CI 0.980-1.002, P = 0.112), respectively. Conclusions: HDLC level was associated with development of type 2 diabetes in both Japanese-Americans and native Japanese. However, these results suggest that the impact of high-density lipoprotein on glucose metabolism might be affected by lifestyle.; Masatoshi Hirano, Shuhei Nakanishi, Mitsunobu Kubota, Shusaku Maeda, Masayasu Yoneda, Kiminori Yamane, Sakurako Kira, Hideo Sasaki and Nobuoki Kohno; Low high-density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes: Data from the Hawaii-Los Angeles-Hiroshima study; Journal of Diabetes Investigation, 2013 (doi: 10.1111/jdi.12170)
• Persistent ID (NDL): info:ndljp/pid/8952581; https://dl.ndl.go.jp/pid/8952581
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-21
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036282
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集