Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis : Implications for cholangiocarcinogenesis

• Material Type: 博士論文
• Title: Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis : Implications for cholangiocarcinogenesis
• Author/Editor: 石井, 康隆
• Author Heading: 石井, 康隆
• Publication Date: 2014-03-23
• Publication Date (W3CDTF): 2014-03-23
• Alternative Title: 原発性硬化性胆管炎ではcyclooxygenase-2とmicrosomal prostaglandin E synathase-1の発現が亢進し、胆管発がんへの関与が示唆される
• Degree grantor/type: 広島大学
• Date Granted: 2014-03-23
• Date Granted (W3CDTF): 2014-03-23
• Dissertation Number: 甲第6375号
• Degree Type: 博士(医学); Philosophy in Medical Science
• Conferring No. (Dissertation): 甲第6375号
• Text Language Code: eng
• Alias of Author: Ishii, Yasutaka
• Subject Heading: primary sclerosing cholangitis; cyclooxygenase-2; microsomal prostaglandin E synthase-1; cholangiocarcinoma
• NDC: 490
• Target Audience: 一般
• Note (General): Cholangiocarcinoma (CCA) occurs frequently in primary sclerosing cholangitis (PSC). Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) induced by inflammation are believed to mediate prostaglandin E2 (PGE2) production thereby promoting carcinogenesis. Their expression in PSC-associated CCA tissues and non-neoplastic bile duct epithelial cells (BDECs) in PSC was investigated. COX-2 and mPGES-1 levels in 15 PSC patients (7 with CCA) were scored using immunohistochemical staining. The results were compared with those obtained in CCA tissues and non-neoplastic BDECs (controls) of 15 sporadic CCA patients. Non-neoplastic BDECs from large and small bile ducts were investigated separately. The mRNA expression levels of COX-2 and mPGES-1 in CCA tissues were analyzed by quantitative polymerase chain reaction. Ki-67 immunostaining was performed to evaluate cell proliferation. COX-2 was strongly expressed in PSC-associated CCA tissues and non-neoplastic BDECs in PSC. This expression was significantly upregulated in both compared with sporadic CCA tissues and non-neoplastic BDECs in sporadic CCA (both P<0.01). mPGES-1 was expressed at moderate to strong levels in PSC. Compared with controls, the expression was significantly higher in non-neoplastic small BDECs (P<0.01). COX-2 mRNA levels were significantly higher in PSC-associated tissues than in sporadic CCA tissues (P<0.01). Conversely, no differences were observed in mPGES-1 mRNA levels. Ki-67 labeling indices were higher in PSC-associated CCA tissues and non-neoplastic BDECs in PSC than in controls. In conclusion, COX-2 and mPGES-1 were highly expressed in PSC-associated CCA tissues and non-neoplastic BDECs in PSC, suggesting the involvement of COX-2 and mPGES-1 in cholangiocarcinogenesis.; Yasutaka Ishii, Tamito Sasaki, Masahiro Serikawa, Tomoyuki Minami, Akihito Okazaki, Masanobu Yukutake, Takashi Ishigaki, Keiichi Kosaka, Teruo Mouri, Satoshi Yoshimi, Akinori Shimizu, Tomofumi Tsuboi and Kazuaki Chayama; Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: Implications for cholangiocarcinogenesis; INTERNATIONAL JOURNAL OF ONCOLOGY 43: 1073-1079, 2013 (DOI: 10.3892/ijo.2013.2038)
• Persistent ID (NDL): info:ndljp/pid/8952592; https://dl.ndl.go.jp/pid/8952592
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-21
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036300
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集