MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer.

• Material Type: 博士論文
• Title: MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer.
• Author/Editor: Naito, Yutaka
• Publication Date: 2014-03-23
• Publication Date (W3CDTF): 2014-03-23
• Alternative Title: スキルス胃癌の間質の線維芽細胞においてMicroRNA-143はcollagen type IIIの発現を制御する
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2014-03-23
• Date Granted (W3CDTF): 2014-03-23
• Dissertation Number: 甲第6383号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第6383号
• Text Language Code: eng
• Subject Heading: Collagen type III; fibroblast; gastric cancer; microRNA-143; transforming growth factor-β
• NDC: 490
• Note (General): Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by rapid disease progression and poor prognosis. MicroRNAs (miRNAs) play crucial roles in cancer development and progression. In the present study, we identified several miRNAs that are expressed at higher levels in scirrhous type GC than in non-scirrhous type GC by miRNA microarray analysis. Among these, microRNA-143 (miR- 143) expression was higher in scirrhous type GC than in non-scirrhous types of GC. In situ hybridization and quantitative RT-PCR analysis showed that miR-143 is expressed by stromal fibroblasts but not by cancer cells. In stromal cells, miR-143 enhanced collagen type III expression in normal gastric fibroblasts and cancerassociated fibroblasts through activation of transforming growth factor-β) /SMAD signaling. Furthermore, high miR-143 expression in GC was associated with worse cancer-specific mortality (P = 0.0141). Multivariate analysis revealed that miR-143 was an independent prognostic factor. Treatment of GC cell lines with 5-aza-2'- deoxycytidine restored the expression of miR-143, and precursor miR-143 caused the inhibition of cancer cell invasion. These data suggest that miR-143 regulates fibrosis of scirrhous type GC through induction of collagen expression in stromal fibroblasts and that miR-143 expression serves as a prognostic marker of GC.; 元資料の権利情報 : Copyright(c) by Author
• Persistent ID (NDL): info:ndljp/pid/8952593; https://dl.ndl.go.jp/pid/8952593
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-21
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036302
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集