TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection

• Material Type: 博士論文
• Title: TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection
• Author/Editor: Naychov, Zheko Dimitrov
• Publication Date: 2013-09-25
• Publication Date (W3CDTF): 2013-09-25
• Alternative Title: TIMP-1 c.T372C遺伝子多型による急性大動脈解離の予測可能性
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2013-09-25
• Date Granted (W3CDTF): 2013-09-25
• Dissertation Number: 甲第6245号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第6245号
• Text Language Code: eng
• Subject Heading: Aortic dissection; SNP; TIMP-1
• NDC: 490
• Note (General): While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD.
• Persistent ID (NDL): info:ndljp/pid/8952607; https://dl.ndl.go.jp/pid/8952607
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2014-11-25
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://ir.lib.hiroshima-u.ac.jp/00036322
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2018-12-03 再収集

2018-12-03 再収集