Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis 4

• Material Type: 博士論文
• ISSN: 0171-9335
• Title: Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis
• Volume: 93 4
• Author/Editor: Yoneyama, Mihoko
• Author Heading: Yoneyama, Mihoko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2014-04
• Publication Date (W3CDTF): 2014-04
• Alternative Title: ビメンチン中間径フィラメントとプレクチンによる浸潤突起の足場形成は癌転移のための浸潤および血管外脱出過程を促進する; ビメンチン チュウカンケイ フィラメント ト プレクチン ニヨル シンジュン トッキ ノ アシバ ケイセイ ワ ガン テンイ ノタメノ シンジュン オヨビ ケッカンガイ ダッシュツ カテイ オ ソクシンスル
• Periodical title: European Journal of Cell Biology
• Degree grantor/type: 弘前大学
• Date Granted: 2014-09-30
• Date Granted (W3CDTF): 2014-09-30
• Dissertation Number: 甲第1867号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第1867号
• Text Language Code: eng
• Subject Heading: 医学
• NDC: 494.95
• Target Audience: 一般
• Note (General): type:Thesis; To investigate the molecular mechanisms of cancer metastasis, we have isolated a high-metastatic bladder cancer cell subpopulation from a low-metastatic cell line by using an in vivo selection system. Cells in the subpopulation showed a high ability to form invadopodia, the filamentous actin (F-actin)-based membrane protrusions that play an essential role in cancer cell invasion. Analysis of the gene expression profile revealed that the expression of an intermediate filament (IF) protein, vimentin and a cytoskeletal linker protein, plectin was up-regulated in the high-metastatic subpopulation compared with the low metastatic cell line. Here we report a novel role of vimentin IF and plectin in metastasis. In invasive bladder cancer cells, the vimentin IF-plectin-invadopodia F-actin link was formed. Disruption of this link severely impaired invadopodia formation, reducing the capacities of extracellular matrix degradation, transendothelial migration and metastasis. In addition, the vimentin assembly into the filaments was required for invadopodia formation. Our results suggest that plectin anchoring invadopodia to vimentin IF scaffolds and stabilizes invadopodia, which is a critical molecular process for cancer cell invasion and extravasation for metastasis.; 掲載誌本文リンク：http://www.sciencedirect.com/science/article/pii/S017193351400048X; identifier:European Journal of Cell Biology, 93(4), 2014, p.157-169
• DOI: info:doi/10.1016/j.ejcb.2014.03.002; https://doi.org/info:doi/10.1016/j.ejcb.2014.03.002
• Persistent ID (NDL): info:ndljp/pid/8953035; https://dl.ndl.go.jp/pid/8953035
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-03-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10129/5477
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2018-06-04 再収集

2018-06-04 再収集

2018-06-04 再収集

2023-03-03 再収集

2023-03-03 再収集