Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome

• Material Type: 博士論文
• ISSN: 0730725x; 18735894
• Title: Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome
• Author/Editor: Machii, Masashi
• Author Heading: Machii, Masashi
• Publication, Distribution, etc.: ELSEVIER
• Publication Date: 2014
• Publication Date (W3CDTF): 2014
• Alternative Title: 終末期肥大型心筋症および拡張型心筋症におけるガドリニウム遅延造影の分布：鑑別診断と心予後の予測
• Degree grantor/type: 浜松医科大学
• Date Granted: 2014-03-07
• Date Granted (W3CDTF): 2014-03-07
• Dissertation Number: 甲第667号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 13802甲第667号
• Text Language Code: eng
• Subject Heading: dilated cardiomyopathy; end-stage hypertrophic cardiomyopathy; late gadolinium enhancement; cardiac magnetic resonance; reverse remodeling
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Background- The prognostic implications of late gadolinium enhancement (LGE) have been evaluated in ischemic and non-ischemic cardiomyopathies. The present study analyzed LGE distribution in patients with end-stage hypertrophic cardiomyopathy (ES-HCM) and with dilated cardiomyopathy (DCM), and tried to identify high risk patients in DCM.Methods- Eleven patients with ES-HCM and 72 with DCM underwent cine- and LGE-cardiac magnetic resonance and ultrasound cardiography. The patient outcome was analyzed retrospectively for 5 years of follow-up.Results- LGE distributed mainly in the inter-ventricular septum, but spread more diffusely into other left ventricular segments in patients with ES-HCM and in a certain part of patients with DCM. Thus, patients with DCM can be divided into three groups according to LGE distribution; no LGE (n=24), localized LGE (localized at septum, n=36), and extensive LGE (spread into other segments, n=12). Reverse remodeling occurred after treatment in patients with no LGE and with localized LGE, but did not in patients with extensive LGE and with ES-HCM. The event-free survival rate for composite outcome (cardiac death, hospitalization for decompensated heart failure or ventricular arrhythmias) was lowest in patients with extensive LGE (92%, 74% and 42% in no LGE, localized LGE, and extensive LGE, p=0.02 vs. no LGE), and was comparable to that in patients with ES-HCM (42%).Conclusions- In DCM, patients with extensive LGE showed no functional recovery and the lowest event-free survival rate that were comparable to patients with ES-HCM. The analysis of LGE distribution may be valuable to predict reverse remodeling and to identify high-risk patients.
• DOI: 10.1016/j.mri.2013.10.011; https://doi.org/10.1016/j.mri.2013.10.011
• Persistent ID (NDL): info:ndljp/pid/8953192; https://dl.ndl.go.jp/pid/8953192
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf; text/html
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2782; https://hama-med.repo.nii.ac.jp/records/2650
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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