Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm

• Material Type: 博士論文
• Title: Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm
• Author/Editor: Sano, Masaki
• Author Heading: Sano, Masaki
• Publication, Distribution, etc.: PLOS (Public Library of Science)
• Publication Date: 2013
• Publication Date (W3CDTF): 2013
• Alternative Title: 腹部大動脈瘤におけるリンパ管新生と血管新生
• Degree grantor/type: 浜松医科大学
• Date Granted: 2014-03-17
• Date Granted (W3CDTF): 2014-03-17
• Dissertation Number: 甲第677号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第677号
• Text Language Code: eng
• Subject Heading: abdominal aorta; lymphatic vasa vasorum; indocyanine green fluorescence lymphography; lymphedema; lymphangiogenesis
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate both angiogenesis and lymphangiogenesis in AAA. Abdominal aortic tissue was harvested either from autopsy (control group) or during open-repair surgery for AAA (AAA group). Adventitial lymphatic vasa vasorum was observed in both groups, but seemed to be no significant morphological changes in AAA. Immunohistochemical studies identified infiltration of lymphatic vessel endothelial hyaluronan receptor (LYVE) -1, vascular endothelial growth factor (VEGF)-C, and matrix metalloproteinase (MMP)-9-positive macrophages and podoplanin and Prox-1-positive microvessels in the intima/media in AAA wall, where hypoxia-inducible factors (HIF)-1α was expressed. VEGF-C and MMP-9 were not expressed in macrophages infiltrating in the adventitia. Intraoperative indocyanine green fluorescence lymphography revealed lymph stasis in intima/medial in AAA.Fluorescence microscopy of the collected samples also confirmed the accumulation of lymph in the intima/media but not in adventitia. These results demonstrate that infiltration of macrophages in intima/media is associated with lymphangiogenesis and angiogenesis in AAA. Lymph-drainage appeared to be insufficient in the AAA wall.
• DOI: info:doi/10.1371/journal.pone.0089830; https://doi.org/info:doi/10.1371/journal.pone.0089830
• Persistent ID (NDL): info:ndljp/pid/8953200; https://dl.ndl.go.jp/pid/8953200
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2790; https://hama-med.repo.nii.ac.jp/records/2672
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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