Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography

• Material Type: 博士論文
• ISSN: 1880-2206
• Title: Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography
• Volume: 13 4
• Author/Editor: Iwanaga, Takashi; Harada, Masafumi; Kubo, Hitoshi; Funakoshi, Yasuhiro; Kunikane, Yamato; Matsuda, Tsuyoshi
• Author Heading: Iwanaga, Takashi; Harada, Masafumi; Kubo, Hitoshi; Funakoshi, Yasuhiro; Kunikane, Yamato; Matsuda, Tsuyoshi
• Publication, Distribution, etc.: Japanese Society for Magnetic Resonance in Medicine
• Publication Date: 2014-12-01
• Publication Date (W3CDTF): 2014-12-01
• Alternative Title: 関心領域自動設定システムを用いた磁気共鳴動脈タギング撮像法と単一光子放射断層撮影における脳灌流定量画像の比較; Comparison of CBF between pCASL and SPECT
• Periodical title: Magnetic Resonance in Medical Sciences
• Degree grantor/type: 徳島大学
• Date Granted: 2014-11-20
• Date Granted (W3CDTF): 2014-11-20
• Dissertation Number: 甲第2781号
• Degree Type: 博士（保健学）
• Conferring No. (Dissertation): 甲第2781号
• Text Language Code: eng
• Subject Heading: arterial spin labeling; iodine-123-N-isopropyl-p-iodoamphetamine; pulsed continuous arterial spin labeling; regional cerebral blood flow; 3-dimensional stereotactic region-of-interest software
• Target Audience: 一般
• Note (General): Purpose: We compared the regional cerebral blood flow (rCBF) obtained by pulsed continuous arterial spin labeling (pCASL) and iodine-123-N-isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) using 3-dimensional stereotactic region-of-interest (ROI) software for automated definition of ROIs in anatomic regions of the brain.Methods: Thirteen patients with cerebrovascular occlusive disease and three with transient ischemic attacks underwent pCASL and IMP SPECT imaging. We compared rCBF values of each anatomic region and calculated the correlation coefficients between pCASL and IMP SPECT. We also calculated the asymmetry index (AI) using ROIs in contralateral regions of the hemispheres.Results: The rCBF values calculated from pCASL and IMP SPECT were comparable in most segments, but rCBF in the thalamus (P < 0.0001) and hippocampus (P = 0.0006) was significantly higher measured by pCASL than IMP SPECT. The correlation of rCBF between pCASL and IMP SPECT in the affected hemisphere (r = 0.50) tended to be lower than that in the normal hemisphere (r = 0.59), but not significantly different (P = 0.25). Moreover, there was a fixed bias for underestimation of rCBF by pCASL (P = 0.0047) in the affected hemisphere. The calculated AI showed a significant relationship between methods (r = 0.79, P < 0.0001).Conclusion: The rCBF obtained by pCASL had positive relationships with IMP SPECT. However, it should be considered that pCASL tends to have a weak relationship with IMP SPECT in some normal regions and regions affected by cerebrovascular occlusive disease.
• DOI: info:doi/10.2463/mrms.2013-0117; https://doi.org/info:doi/10.2463/mrms.2013-0117
• Persistent ID (NDL): info:ndljp/pid/8977103; https://dl.ndl.go.jp/pid/8977103
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-03-01T07:09:42+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/106376
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp