Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study. 2

• Material Type: 博士論文
• ISSN: 0959-2989
• Title: Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.
• Volume: 25 2
• Author/Editor: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• Author Heading: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• Publication, Distribution, etc.: IOS press
• Publication Date: 2014-09-09; 25 2
• Publication Date (W3CDTF): 2014-09-09
• Alternative Title: 心臓血管外科領域におけるゼラチンシートの止血効果、癒着防止効果の検討
• Periodical title: Bio-medical materials and engineering
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Date Granted (W3CDTF): 2015-03-16
• Dissertation Number: 甲第632号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第632号
• Text Language Code: eng
• Subject Heading: gelatin; fibrin glue; surgical sealant; anti-adhesion; postoperative adhesions
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND:The bi1ayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE:To examine the feasibility of gelatin sealing sheets using a canine aterial hemorrhage mode1. METHODS:In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make as mall hole, and a gelatin(i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS:From the degradation study, 4h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS:The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.; 博士（医学）・甲第632号・平成27年3月16日; Copyright ©2015 IOS Press; identifier:Bio-medical materials and engineering Vol.25 No.2 p.157-168 (2015); identifier:09592989; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2963; identifier:Bio-medical materials and engineering, 25(2): 157-168
• DOI: info:doi/10.3233/bme-151266; https://doi.org/info:doi/10.3233/bme-151266
• Persistent ID (NDL): info:ndljp/pid/9277970; https://dl.ndl.go.jp/pid/9277970
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-05-01T13:23:17+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2963
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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