Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer
• Volume: 62 3-4
• Author/Editor: Saijo, Yasuyo; Furumoto, Hiroyuki; Yoshida, Kanako; Nishimura, Masato; Irahara, Minoru
• Author Heading: Saijo, Yasuyo; Furumoto, Hiroyuki; Yoshida, Kanako; Nishimura, Masato; Irahara, Minoru
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2015-08
• Publication Date (W3CDTF): 2015-08
• Alternative Title: 浸潤性子宮頸癌における血管内皮増殖因子の発現と微小血管密度の重要性について
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2015-03-19
• Date Granted (W3CDTF): 2015-03-19
• Dissertation Number: 甲第2800号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2800号
• Text Language Code: eng
• Subject Heading: cervical cancer; vascular endothelial growth factor; microvessel density; bevacizumab; angiogenesis
• Target Audience: 一般
• Note (General): To determine whether vascular endothelial growth factor (VEGF) expression and microvessel density are predictive of prognosis in cases of invasive cervical cancer, correlations among VEGF expression, microvessel density, and clinicopathological parameters were identified. VEGF expression was evaluated in 50 cervical cancer samples by immunohistochemical staining. Microvessel density was assessed by immunostaining for CD31-positive endothelial cells in the most vascularized areas of tumors. VEGF expression and microvessel density were significantly higher in adenocarcinomas than in squamous cell carcinomas. However, in cases of adenocarcinoma, no significant correlations were found among VEGF expression, microvessel density, and clinicopathological parameters. In contrast, for squamous cell carcinomas, microvessel density was significantly higher in cases at an advanced stage and in those with several other poor prognostic factors. The finding that cervical adenocarcinomas exhibited greater VEGF expression and microvessel density than squamous cell carcinomas may explain the poorer prognosis of adenocarcinoma compared with squamous cell carcinoma. Moreover, microvessel density in squamous cell carcinomas was significantly correlated with poor prognostic factors. Therefore, there is possibility that bevacizumab, a humanized monoclonal antibody against VEGF-A, may be useful in the initial treatment targeting angiogenesis for early-stage cervical cancer.
• DOI: info:doi/10.2152/jmi.62.154; https://doi.org/info:doi/10.2152/jmi.62.154
• Persistent ID (NDL): info:ndljp/pid/9374992; https://dl.ndl.go.jp/pid/9374992
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-06-02T13:06:44+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111271
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-04 再収集