Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats

• Material Type: 博士論文
• Title: Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats
• Author/Editor: Tsuji, Kojun
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2015-03-23
• Publication Date (W3CDTF): 2015-03-23
• Alternative Title: Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats; ラット上喉頭神経電気刺激中における嚥下頻度の変化
• Degree grantor/type: 新潟大学
• Date Granted: 2015-03-23
• Date Granted (W3CDTF): 2015-03-23
• Dissertation Number: 甲第4015号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第4015号
• Text Language Code: eng
• Subject Heading: Swallowing; Superior laryngeal nerve; Rat; Central pattern generator; Nucleus tractus solitarii
• Note (General): The aim of the present study was to investigate the adaptation of the swallowing reflex in terms of reduced swallowing reflex initiation following continuous superior laryngeal nerve stimulation. Forty-four male Sprague Dawley rats were anesthetized with urethane. To identify swallowing, electromyographic activity of the left mylohyoid and thyrohyoid muscles was recorded. To evoke the swallowing response, the superior laryngeal nerve (SLN), recurrent laryngeal nerve, or cortical swallowing area was electrically stimulated. Repetitive swallowing evoked by continuous SLN stimulation was gradually reduced, and this reduction was dependent on the resting time duration between stimulations. Prior SLN stimulation also suppressed subsequent swallowing initiation. The reduction in evoked swallows induced by recurrent laryngeal nerve or cortical swallowing area stimulation was less than that following superior laryngeal nerve stimulation. Decerebration had no effect on the reduction in evoked swallows. Prior subthreshold stimulation reduced subsequent initiation of swallowing, suggesting that there was no relationship between swallowing movement evoked by prior stimulation and the subsequent reduction in swallowing initiation. Overall, these data suggest that reduced sensory afferent nerve firing and/or trans-synaptic responses, as well as part of the brainstem central pattern generator, are involved in adaptation of the swallowing reflex following continuous stimulation of swallow-inducing peripheral nerves and cortical areas.; 学位の種類: 博士（歯学）. 報告番号: 甲第4015号. 学位記番号: 新大院博（歯）甲第328号. 学位授与年月日: 平成27年3月23日; Brain Research Bulletin. 2015, 111, 53-61.; 新大院博（歯）甲第328号; 元資料の権利情報 : Copyright (C) 2014 Elsevier
• DOI: info:doi/10.1016/j.brainresbull.2014.12.008; https://doi.org/info:doi/10.1016/j.brainresbull.2014.12.008
• Persistent ID (NDL): info:ndljp/pid/9424956; https://dl.ndl.go.jp/pid/9424956
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/32184
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp