Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour

• Material Type: 博士論文
• Title: Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour
• Author/Editor: Watanabe, Gen
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2015-03-23
• Publication Date (W3CDTF): 2015-03-23
• Alternative Title: Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour; バレット食道における腸上皮化生は前腫瘍状態というより副現象かもしれない，そしてCDX2陽性噴門腺型上皮が微小なバレット腫瘍と関連する
• Degree grantor/type: 新潟大学
• Date Granted: 2015-03-23
• Date Granted (W3CDTF): 2015-03-23
• Dissertation Number: 乙第2188号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第2188号
• Text Language Code: eng
• Subject Heading: Barrett’s oesophagus; cardiac-type epithelium; CDX2; intestinal metaplasia; tumour immunophenotype
• Note (General): Aims: Although intestinal-type epithelium in Barrett’s oesophagus has been traditionally recognised as having a distinct malignant potential, whether this also holds true for cardiac-type epithelium remains controversial. The aim of this study was to identify highly associated type of epithelium with Barrett’s tumour. Methods and results: We analysed tumours and the corresponding background mucosa with special regard to tumour size in 40 cases of superficial Barrett’s tumour by using mmunohistochemical staining for CDX2, CD10, MUC2, MUC5AC, and MUC6. Intestinal metaplasia in tumour-adjacent mucosa was not associated with tumour size, but was significantly correlated with the extent of Barrett’s oesophagus (P < 0.001). Majority (69.2%, 9/13) of small tumours (≤10 mm in size) had no intestinal metaplasia in adjacent non-neoplastic mucosae. Minute (≤5 mm) tumours were significantly associated with gastric immunophenotype (P < 0.001). Purely gastric-immunophenotype tumour cells expressed CDX2, and cardiac-type epithelium adjacent to small tumours also displayed low-level CDX2 expression. Conclusions: Our data suggest that intestinal metaplasia in Barrett’s oesophagus is an epiphenomenon rather than a pre-neoplastic condition and that CDX2-positive cardiac-type epithelium is highly associated with minute Barrett’s tumour. Further prospective studies are needed to evaluate the risk of malignancy of cardiac-type epithelium with regard to sub-morphological intestinalisation.; 学位の種類: 博士（医学）. 報告番号: 乙第2188号. 学位記番号: 新大博（医）乙第1777号. 学位授与年月日: 平成27年3月23日; Histopathology. 2015, 66(2), 201-214.; 新大博（医）乙第1777号; 元資料の権利情報 : Copyright (C) 2014 Watanabe G. et al. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.; 開始ページ : 1; 終了ページ : 14
• DOI: info:doi/10.1111/his.12486; https://doi.org/info:doi/10.1111/his.12486
• Persistent ID (NDL): info:ndljp/pid/9425155; https://dl.ndl.go.jp/pid/9425155
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/32287
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp