Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures

• Material Type: 博士論文
• ISSN: 1343-1420
• Title: Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures
• Volume: 58 3-4
• Author/Editor: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• Author Heading: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• Publication Date: 2011-08
• Publication Date (W3CDTF): 2011-08
• Alternative Title: 婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる; NK-1 receptor antagonism decreases PONV
• Periodical title: The journal of medical investigation : JMI
• Degree grantor/type: 徳島大学
• Date Granted: 2015-04-23
• Date Granted (W3CDTF): 2015-04-23
• Dissertation Number: 甲第2854号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第2854号
• Text Language Code: eng
• Subject Heading: neurokinin-1 receptor; post-operative nausea and vomiting; aprepitant; laparoscopic gynecological surgery
• Target Audience: 一般
• Note (General): Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
• DOI: info:doi/10.2152/jmi.58.246; https://doi.org/info:doi/10.2152/jmi.58.246
• Persistent ID (NDL): info:ndljp/pid/9425189; https://dl.ndl.go.jp/pid/9425189
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/83838
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp