Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse

• Material Type: 博士論文
• Title: Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse
• Author/Editor: Nojiri, Ayumi
• Author Heading: Nojiri, Ayumi
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2013-01-01
• Publication Date (W3CDTF): 2013-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2013-12-18
• Date Granted (W3CDTF): 2013-12-18
• Dissertation Number: 甲医学第1647号
• Degree Type: 博士 (医学)
• Conferring No. (Dissertation): 甲医学第1647号
• Text Language Code: eng
• Alias of Author: ノジリ, アユミ; 野尻, 亜弓
• Subject Heading: Min mouse; X-irradiation; DSS; colon
• Target Audience: 一般
• Note (General): application/pdf; Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of age (at 0 experimental week) and 2% DSS in drinking water was administered at 5 or 11 experimental weeks. Mice were sacrificed at 16 weeks and incidence and multiplicity of colonic tumors were assessed. Incidence of colonic tumors in Min mouse was increased from 33.3% to 100% (p<0.05) with X-irradiation alone, whereas no tumors were developed in WT mice. In DSS-treated Min mice, X-irradiation increased the number of colonic tumors. Total number of colonic tumors was increased 1.57 times to 30.7±3.83 tumors/mouse with X-irradiation+DSS at 5 weeks comapared to 19.6±2.9 in corresponding DSS alone group (p<0.05). When the duration of inflammation was compared, longer period of DSS effect promoted more colonic tumorigenesis. Collectively, we conclude that X-irradiation and DSS-induced inflammation act synergistically for colonic tumorigenesis.; 本文 / Aichi Canc Ctr, Res Inst, Div Oncol Pathol ; Mie Univ, Grad Sch Med, Dept Pathol & Matrix Biol; 5p; http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=POCPA9_2013_v14n7_4135
• DOI: info:doi/10.7314/APJCP.2013.14.7.4135; https://doi.org/info:doi/10.7314/APJCP.2013.14.7.4135
• Persistent ID (NDL): info:ndljp/pid/9425194; https://dl.ndl.go.jp/pid/9425194
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=POCPA9_2013_v14n7_4135
• Periodical Title (URI): http://hdl.handle.net/10076/14572; https://mie-u.repo.nii.ac.jp/records/7816
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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