Impact of closed-system drug transfer device on exposure of environment and healthcare provider to cyclophosphamide in Japanese hospital

• Material Type: 博士論文
• Title: Impact of closed-system drug transfer device on exposure of environment and healthcare provider to cyclophosphamide in Japanese hospital
• Author/Editor: Miyake, Tomohiro
• Author Heading: Miyake, Tomohiro
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2013-01-01
• Publication Date (W3CDTF): 2013-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2013-12-18
• Date Granted (W3CDTF): 2013-12-18
• Dissertation Number: 甲医学第1648号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1648号
• Text Language Code: eng
• Alias of Author: ミヤケ, トモヒロ; 三宅, 知宏
• Subject Heading: Cyclophosphamide; Surface contamination; exposure of healthcare provider; PhaSeal; Japanese guidelines
• Target Audience: 一般
• Note (General): application/pdf; In spite of current recommended safe handling procedures, the potential for the exposure of healthcare providers to hazardous drugs exists in the workplace. A reliance on biological safety cabinets to provide total protection against the exposure to hazardous drugs is insufficient. Preventing workplace contamination is the best strategy to minimize cytotoxic drug exposure in healthcare providers. This study was conducted to compare surface contamination and personnel exposure to cyclophosphamide before and after the implementation of a closedsystem drug transfer device, PhaSeal, under the influence of cleaning according to the Japanese guidelines. Personnel exposure was evaluated by collecting 24 h urine samples from 4 pharmacists. Surface contamination was assessed by the wiping test. Four of 6 wipe samples collected before PhaSeal indicated a detectable level of cyclophosphamide. About 7 months after the initiation of PhaSeal, only one of 6 wipe samples indicated a detectable level of cyclophosphamide. Although all 4 employees who provided urine samples had positive results for the urinary excretion of cyclophosphamide before PhaSeal, these levels returned to minimal levels in 2 pharmacists after PhaSeal. In combination with the biological safety cabinet and cleaning according to the Japanese guidelines, PhaSeal further reduces surface contamination and healthcare providers exposure to cyclophosphamide to almost undetectable levels.; 本文 / Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine; 7p; http://link.springer.com/article/10.1186/2193-1801-2-273
• DOI: info:doi/10.1186/2193-1801-2-273; https://doi.org/info:doi/10.1186/2193-1801-2-273
• Persistent ID (NDL): info:ndljp/pid/9425195; https://dl.ndl.go.jp/pid/9425195
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://link.springer.com/article/10.1186/2193-1801-2-273
• Periodical Title (URI): http://hdl.handle.net/10076/14573; https://mie-u.repo.nii.ac.jp/records/7817
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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