Gemcitabine-based chemoradiotherapy followed by surgery for borderline resectable and locally unresectable pancreatic ductal adenocarcinoma : significance of the CA19-9 reduction rate and intratumoral human equilibrative nucleoside transporter-1 expression

• Material Type: 博士論文
• Title: Gemcitabine-based chemoradiotherapy followed by surgery for borderline resectable and locally unresectable pancreatic ductal adenocarcinoma : significance of the CA19-9 reduction rate and intratumoral human equilibrative nucleoside transporter-1 expression
• Author/Editor: Kobayashi, Motoyuki
• Author Heading: Kobayashi, Motoyuki
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2013-01-01
• Publication Date (W3CDTF): 2013-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2013-12-18
• Date Granted (W3CDTF): 2013-12-18
• Dissertation Number: 甲医学第1649号
• Degree Type: 博士 (医学)
• Conferring No. (Dissertation): 甲医学第1649号
• Text Language Code: eng
• Alias of Author: コバヤシ, モトユキ; 小林, 基之
• Subject Heading: pancreatic cancer; preoperative chemoradiotherapy; resectabilty; human equilibrative nucleoside transporter 1 expression; AC - adjuvant chemotherapy; BR - borderline resectable
• Target Audience: 一般
• Note (General): application/pdf; OBJECTIVES: This study aimed to evaluate the efficacy of gemcitabine-based chemoradiotherapy followed by surgery (gem-CRTS) for pancreatic ductal adenocarcinoma (PDAC) for borderline resectable (BR) and locally unresectable (UR) tumors.METHODS: One hundred patients with PDAC who underwent the gem-CRTS protocol were classified into 3 groups, namely, resectable (R; 14), BR (44), and UR (42). After chemoradiotherapy, the patients were reassessed for curative-intent resection.RESULTS: At reassessment, distant metastases became apparent in 27% of R patients, in 12% of BR patients, and in 18% of UR patients. The multivariate analysis of preoperative factors indicated that the CA19-9 reduction rate was an independent prognostic factor in the BR group. Among reassessed patients, the resection rate was 63.6% in R, 83.7% in BR, and 50.0% in UR patients. In 63 patients that underwent curative-intent resection, the 3-year survival rate was 83.3% in R, 33.0% in BR, and 7.8% in UR patients. Using multivariate analysis, the independent prognostic factor was found to be the surgical margin in BR patients and human equilibrative nucleoside transporter 1 expression in UR patients.CONCLUSIONS: We consider that our gem-CRTS protocol, even for locally UR PDAC, allows for the identification of candidates for aggressive resection at the time of reassessment and improved prognosis in the patients with positive human equilibrative nucleoside transporter 1 expression.; 本文 / Mie Univ, Sch Med, Dept Hepatobiliary Pancreat & Transplant Surg; 15p; http://journals.lww.com/pancreasjournal/Fulltext/2014/04000/Gemcitabine_Based_Chemoradiotherapy_Followed_by.5.aspx
• DOI: info:doi/10.1097/MPA.0000000000000059; https://doi.org/info:doi/10.1097/MPA.0000000000000059
• Persistent ID (NDL): info:ndljp/pid/9425196; https://dl.ndl.go.jp/pid/9425196
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-07-01T13:17:09+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://journals.lww.com/pancreasjournal/Fulltext/2014/04000/Gemcitabine_Based_Chemoradiotherapy_Followed_by.5.aspx
• Periodical Title (URI): http://hdl.handle.net/10076/14574; https://mie-u.repo.nii.ac.jp/records/7818
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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