Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.

• Material Type: 博士論文
• Title: Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.
• Author/Editor: Yamauchi, Yoshinori; Tsuruga, Eichi; Nakashima, Kazuki; Sawa, Yoshihiko; Ishikawa, Hiroyuki
• Author Heading: Yamauchi, Yoshinori; Tsuruga, Eichi; Nakashima, Kazuki; Sawa, Yoshihiko; Ishikawa, Hiroyuki
• Publication Date: 2014-03-15
• Publication Date (W3CDTF): 2014-03-15
• Alternative Title: Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2014-03-15
• Date Granted (W3CDTF): 2014-03-15
• Dissertation Number: 甲第254号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第254号
• Text Language Code: eng
• Subject Heading: トロポエラスチン; Fibulin-4; 歯肉線維芽細胞; 弾性線維; tropoelastin; human gingival fibroblasts; elastic fiber; Fibulin; fibrillin; microfibrils
• Target Audience: 一般
• Note (General): Elastic system fibers consist of microfibrils and tropoelastin. During development, microfibrils act as a template on which tropoelastin is deposited. Fibrillin-1 is the major component of microfibrils. It is not clear whether elastic fiber-associated molecules, such as fibulins, contribute to tropoelastin deposition. Among the fibulin family, fibulin-2, -4 and -5 are capable of binding to tropoelastin and fibrillin-1. In the present study, we used the RNA interference (RNAi) technique to establish individual gene-specific knockdown of fibulin-2, -4 and -5 in elastin-producing cells (human gingival fibroblasts; HGF). We then examined the extracellular deposition of tropoelastin using immunofluorescence. RNAi-mediated down-regulation of fibulin-4 and -5 was responsible for the diminution of tropoelastin deposition. Suppression of fibulin-5 appeared to inhibit the formation of fibrillin-1 microfibrils, while that of fibulin-4 did not. Similar results to those for HGF were obtained with human dermal fibroblasts. These results suggest that fibulin-4 and -5 may be associated in different ways with the extracellular deposition of tropoelastin during elastic fiber formation in elastin-producing cells in culture.; Acta Histochem Cytochem. 2010 Dec 29;43(6):131-8. doi: 10.1267/ahc.10026. Epub 2010 Nov 20.; J-STAGE
• Persistent ID (NDL): info:ndljp/pid/9479188; https://dl.ndl.go.jp/pid/9479188
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Date Created (W3CDTF): 2014-04-28
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): Acta Histochem Cytochem. 2010 Dec 29;43(6):131-8. doi: 10.1267/ahc.10026. Epub 2010 Nov 20.; https://www.jstage.jst.go.jp/article/ahc/43/6/43_10026/_article
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/10
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-08-05 再収集

2023-08-05 再収集

2023-08-05 再収集

2023-12-07 再収集

2023-12-07 再収集