In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.

• Material Type: 博士論文
• Title: In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
• Author/Editor: Ota, Nobutaka; Ohno, Jun; Seno, Kei; Taniguchi, Kunihisa; Ozeki, Satoru
• Author Heading: Ota, Nobutaka; Ohno, Jun; Seno, Kei; Taniguchi, Kunihisa; Ozeki, Satoru
• Publication Date: 2014-03-15
• Publication Date (W3CDTF): 2014-03-15
• Alternative Title: In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2014-03-15
• Date Granted (W3CDTF): 2014-03-15
• Dissertation Number: 甲第256号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第256号
• Text Language Code: eng
• Subject Heading: aldehyde dehydrogenase 1; ral squamous cell carcinoma; cancer-initiating cell; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Immunoenzyme Techniques; In Vitro Techniques; Isoenzymes; Male; Middle Aged; Mouth Neoplasms; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retinal Dehydrogenase; Tumor Cells, Cultured; Tumor Markers, Biological
• Target Audience: 一般
• Note (General): Aldehyde dehydrogenase isoform 1 (ALDH1) is a useful marker of cancer-initiating cells (CICs) in various organs. In this study, we investigated whether alterations in ALDH1 immunostaining and enzymatic activity in tumor cell populations predicted clinicopathological factors of prognostic importance for cancer progression and contributed to the characteristics of CICs in cisplatin-treated oral squamous cell cancer (OSCC) cells. We evaluated the association between the proportion of ALDH1-positive tumor cells and the clinicopathological features in 90 patients with OSCC. We also examined ALDH1 enzymatic activity, ABCG2 expression, invasive capacity and the ability to self-renew in OSCC cells treated with or without cisplatin. The clinicopathological results showed that elevated ALDH1 expression correlated with local recurrence. In in vitro experiments, the percentage of cells exhibiting ALDH1 enzymatic activity significantly increased among cisplatin-surviving cells (CiSCs) according to flow cytometry. Furthermore, CiSCs demonstrated upregulated expression of ABCG2, their invasive capacity increased, and their ability to generate cancer spheres was enhanced. An increased population of cells exhibiting ALDH1 immunostaining is a predictive marker of local recurrence. ALDH1 expression and activity contributes to the characteristics of CICs in OSCC.; Int J Oncol. 2014 Feb;44(2):435-42. doi: 10.3892/ijo.2013.2188. Epub 2013 Nov 27.; International Journal of Oncology
• Persistent ID (NDL): info:ndljp/pid/9479211; https://dl.ndl.go.jp/pid/9479211
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Date Created (W3CDTF): 2015-03-24
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): Int J Oncol. 2014 Feb;44(2):435-42. doi: 10.3892/ijo.2013.2188. Epub 2013 Nov 27.; http://www.spandidos-publications.com/ijo/44/2/435
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/39
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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