Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects.

• Material Type: 博士論文
• Title: Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects.
• Author/Editor: Yanagi, Tsukasa; Kajiya, Hiroshi; Kawaguchi, Minoru; Kido, Hirofumi; Fukushima, Tadao
• Author Heading: Yanagi, Tsukasa; Kajiya, Hiroshi; Kawaguchi, Minoru; Kido, Hirofumi; Fukushima, Tadao
• Publication Date: 2015-03-14
• Publication Date (W3CDTF): 2015-03-14
• Alternative Title: Photothermal stress triggered by near infrared-irradiated carbon nanotubes promotes bone deposition in rat calvarial defects.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2015-03-14
• Date Granted (W3CDTF): 2015-03-14
• Dissertation Number: 甲第260号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第260号
• Text Language Code: eng
• Subject Heading: 温熱刺激; カーボンナノチューブ; 近赤外線; DNA/プロタミン複合体; 骨形成; Photothermal stress; Carbon nano tubes; Near infrared ray; DNA/Protamine complex; Osteogenesis
• Target Audience: 一般
• Note (General): The bone regenerative healing process is often prolonged, with a high risk of infection particularly in elderly and diseased patients. A reduction in healing process time usually requires mechanical stress devices, chemical cues, or laser/thermal therapies. Although these approaches have been used extensively for the reduction of bone healing time, the exact mechanisms involved in thermal stress-induced bone regeneration remain unclear. In this study, we investigated the effect of optimal hyperthermia on rat calvarial defects invivo and on osteogenesis invitro. Photothermal stress stimulation was carried out using a new photothermal device, composed of an alginate gel including in carbon nanotubes and their irradiator with near-infrared light. Photothermal stress (15 min at 42℃, every day), trigged by near-infrared-induced carbon nanotube, promoted bone deposition in critical-sized calvarial defects compared with nonthermal stress controls. We recently reported that our novel DNA/protamine complex scaffold induces bone regeneration in calvarial defects. In this study, photothermal stress upregulated bone deposition in DNA/protamine-engrafted calvarial defects. Furthermore, photothermal stress significantly induced expression of osteogenic related genes in a time-dependent manner, including alkaline phosphatase, osterix, and osteocalcin. This was observed in DNA/protamine cells, which were expanded from regenerated tissue engrafted into the DNA/protamine scaffold, as well as in human MG63 preosteoblasts. In summary, this novel carbon nanotube-based photothermal stress approach upregulated expression of osteogenic-related genes in preosteoblasts, resulting in promotion of mineral deposition for enhanced bone repair.; J Biomater Appl. 2015 Mar;29(8):1109-18. doi: 10.1177/0885328214556913. Epub 2014 Oct 20.
• Persistent ID (NDL): info:ndljp/pid/9479212; https://dl.ndl.go.jp/pid/9479212
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Date Created (W3CDTF): 2015-03-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): J Biomater Appl. 2015 Mar;29(8):1109-18. doi: 10.1177/0885328214556913. Epub 2014 Oct 20.
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/40
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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