Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.

• Material Type: 博士論文
• Title: Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.
• Author/Editor: Takata, Shunsuke; Sawa, Yoshihiko; Uchiyama, Takanobu; Ishikawa, Hiroyuki
• Author Heading: Takata, Shunsuke; Sawa, Yoshihiko; Uchiyama, Takanobu; Ishikawa, Hiroyuki
• Publication Date: 2015-03-14
• Publication Date (W3CDTF): 2015-03-14
• Alternative Title: Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2015-03-14
• Date Granted (W3CDTF): 2015-03-14
• Dissertation Number: 甲第262号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第262号
• Text Language Code: eng
• Subject Heading: diabetes; glomerular endothelial cells; toll-like receptor 4; streptozotocin; KK/TaJcl
• Target Audience: 一般
• Note (General): Diabetic conditions promote glomerulosclerosis by mesangial cells but the mechanisms are not fully elucidated. The present study evaluated the expression of toll-like receptor 4 in glomerular endothelial cells in the streptozotocin (STZ)-induced type 1 diabetic mouse (ICR-STZ) and the type 2 diabetic KK/TaJcl mouse which were fed a high fat diet feed (KK/Ta-HF). In the ICR-STZ and KK/Ta-HF almost glomeruli were immunostained with anti-TLR4 but there was no glomerulus immunostained by ani-TLR4 in the control ICR and KK/Ta. Laser-scanning confocal microscopy showed that the TLR4-positive region did not coincide with the podoplanin-positive region but coincide with the PECAM-1- and VE-cadherin-positive regions in the glomeruli of the ICR-STZ and KK/Ta-HF. The in situ hybridization showed that almost signals for TLR4 mRNA were present in the glomerulus of the ICR-STZ and KK/Ta-HF to a stronger extent than in the control ICR and KK/Ta. These suggest that glomerular endothelial cells usually express the TLR4 gene and hyperglycemia in the diabetic condition induces the TLR4 protein expression in the glomerular capillary endothelial cells. Cytokine productions through the TLR signaling pathway in glomerular endothelial cells may allow mesangial cells to produce extracellular matrix proteins in the diabetic milieu.; Acta Histochem Cytochem. 2013 Feb 28;46(1):35-42. doi: 10.1267/ahc.13002. Epub 2013 Feb 15.; J-STAGE
• Persistent ID (NDL): info:ndljp/pid/9479216; https://dl.ndl.go.jp/pid/9479216
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Date Created (W3CDTF): 2015-07-06
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): Acta Histochem Cytochem. 2013 Feb 28;46(1):35-42. doi: 10.1267/ahc.13002. Epub 2013 Feb 15.; https://www.jstage.jst.go.jp/article/ahc/46/1/46_13002/_article
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/44
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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