Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle.

• Material Type: 博士論文
• Title: Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle.
• Volume: 51
• Author/Editor: 石田, 美織
• Author Heading: 石田, 美織
• Publication Date: 2015; 51
• Publication Date (W3CDTF): 2015
• Periodical title: Journal of smooth muscle research
• Degree grantor/type: 旭川医科大学
• Date Granted: 2015-06-30
• Date Granted (W3CDTF): 2015-06-30
• Dissertation Number: 甲第482号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第482号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:application/pdf; Ciliary muscle is a smooth muscle characterized by a rapid response to muscarinic receptor stimulation and sustained contraction. Although it is evident that these contractions are Ca(2+)-dependent, detailed molecular mechanisms are still unknown. In order to elucidate the role of Ser/Thr protein phosphatase 2A (PP2A) in ciliary muscle contraction, we examined the effects of okadaic acid and other PP2A inhibitors on contractions induced by carbachol (CCh) and ionomycin in bovine ciliary muscle strips (BCM). Okadaic acid inhibited ionomycin-induced contraction, while it did not cause significant changes in CCh-induced contraction. Fostriecin showed similar inhibitory effects on the contraction of BCM. On the other hand, rubratoxin A inhibited both ionomycin- and CCh-induced contractions. These results indicated that PP2A was involved at least in ionomycin-induced Ca(2+)-dependent contraction, and that BCM had a unique regulatory mechanism in CCh-induced contraction.
• DOI: info:doi/10.1540/jsmr.51.10.; https://doi.org/info:doi/10.1540/jsmr.51.10.
• Persistent ID (NDL): info:ndljp/pid/9479394; https://dl.ndl.go.jp/pid/9479394
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20150630_K482
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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