CG-containing oligonucleotides and transcription factor binding motifs evidently enriched in human pericentric regions.

• Material Type: 博士論文
• ISSN: 1341-7568
• Title: CG-containing oligonucleotides and transcription factor binding motifs evidently enriched in human pericentric regions.
• Volume: 90 1
• Author/Editor: WADA, Yoshiko
• Author Heading: WADA, Yoshiko
• Publication, Distribution, etc.: 日本遺伝学会
• Publication Date: 2015-06-25
• Publication Date (W3CDTF): 2015-06-25
• Periodical title: Genes & Genetic Systems
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2015-03-10
• Date Granted (W3CDTF): 2015-03-10
• Dissertation Number: 乙第415号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第415号
• Text Language Code: eng
• Subject Heading: CG dinucleotide; chromocenter; oligonucleotide composition; pericentric heterochromatin; self-organizing map
• Target Audience: 一般
• Note (General): Unsupervised data mining capable of extracting a wide range of information from big sequence data without prior knowledge or particular models is highly desirable in an era of big data accumulation for research on genes, genomes and genetic systems. By handling oligonucleotide compositions in genomic sequences as high-dimensional data, we have previously modified the conventional SOM (self-organizing map) for genome informatics and established BLSOM for oligonucleotide composition, which can analyze more than ten million sequences simultaneously and is thus suitable for big data analyses. Oligonucleotides often represent motif sequences responsible for sequence-specific binding of proteins such as transcription factors. The distribution of such functionally important oligonucleotides is probably biased in genomic sequences, and may differ among genomic regions. When constructing BLSOMs to analyze pentanucleotide composition in 50-kb sequences derived from the human genome in this study, we found that BLSOMs did not classify human sequences according to chromosome but revealed several specific zones, which are enriched for a class of CG-containing pentanucleotides; these zones are composed primarily of sequences derived from pericentric regions. The biological significance of enrichment of these pentanucleotides in pericentric regions is discussed in connection with cell type- and stage-dependent formation of the condensed heterochromatin in the chromocenter, which is formed through association of pericentric regions of multiple chromosomes.; Thesis or Dissertation; 雑誌掲載時のタイトル：CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions; 平成26年度; 10.1266/ggs.90.43
• DOI: info:doi/10.1266/ggs.90.43; https://doi.org/info:doi/10.1266/ggs.90.43
• Persistent ID (NDL): info:ndljp/pid/9479452; https://dl.ndl.go.jp/pid/9479452
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-08-01T14:40:15+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/10531; https://shiga-med.repo.nii.ac.jp/records/1374
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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