Sevoflurane in combination with propofol， not thiopental， induces a more robust neuroapoptosis than sevoflurane alone in the neonatal mouse brain

• Material Type: 博士論文
• Title: Sevoflurane in combination with propofol， not thiopental， induces a more robust neuroapoptosis than sevoflurane alone in the neonatal mouse brain
• Author/Editor: Tagawa, Tsuyoshi
• Author Heading: Tagawa, Tsuyoshi
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2014-01-01
• Publication Date (W3CDTF): 2014-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2014-09-17
• Date Granted (W3CDTF): 2014-09-17
• Dissertation Number: 乙医学第974号
• Degree Type: 博士 (医学)
• Conferring No. (Dissertation): 乙医学第974号
• Text Language Code: eng
• Alias of Author: タガワ, ツヨシ; 田川, 剛志
• Subject Heading: Sevoflurane; Apoptosis; Children
• Target Audience: 一般
• Note (General): application/pdf; Purpose Sevoflurane is the most widely used volatile anesthetic of general anesthesia. In children and neonates, it is commonly used alone or in combination with thiopental or propofol. A few recent studies reported that sevoflurane induced neuronal death in the developing rodent brain. We measured the neurotoxicity of these anesthetics at clinical doses, alone and in combination, in the developing mouse brain. Methods Seven-day-old C57BL/6 mice were randomly assigned to 6 treatment groups. Three groups were exposed to 3% sevoflurane for 6 h after injection of saline, thiopental (5 mg/kg), or propofol (10 mg/kg), whereas three groups were exposed to room air for 6 h after injection of equal doses of saline, thiopental, or propofol. Apoptosis in the hippocampal CA1 region (CA1) and retrosplenial cortex (RC) was assessed using caspase-3 immunostaining. Results Sevoflurane alone caused significantly higher apoptosis in the CA1 compared with saline plus air (P = 0.04). Sevoflurane in combination with propofol resulted in significantly greater numbers of apoptotic neurons than svoflurane alone in both the CA1 and the RC (P = 0.04). However, there was no significant difference in apoptotic neuron density in both the regions between the groups treated with sevoflurane alone and in combination with thiopental (P = 0.683). Conclusion Sevoflurane alone can induce neuronal apoptosis, and this effect is enhanced by propofol. Thiopental did not exacerbate the neurotoxicity of sevoflurane. There is the possibility that the combination of sevoflurane and propofol is more harmful anesthetic technique than sevoflulane alone in pediatric patients.; 本文 / Department of Neural Regeneration and Cell communication, MieUniversity Graduate School of Medicine, Mie, Japan; 24p; http://link.springer.com/article/10.1007%2Fs00540-014-1822-x
• DOI: info:doi/10.1007/s00540-014-1822-x; https://doi.org/info:doi/10.1007/s00540-014-1822-x
• Persistent ID (NDL): info:ndljp/pid/9529697; https://dl.ndl.go.jp/pid/9529697
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-11-01T14:53:18+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://link.springer.com/article/10.1007%2Fs00540-014-1822-x
• Periodical Title (URI): http://hdl.handle.net/10076/14716; https://mie-u.repo.nii.ac.jp/records/7825
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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