Systemic CD8+ T Cell-mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-induced Tumor Necrosis Factor Receptor

• Material Type: 博士論文
• Title: Systemic CD8+ T Cell-mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-induced Tumor Necrosis Factor Receptor
• Author/Editor: Ishihara, Mikiya
• Author Heading: Ishihara, Mikiya
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2014-01-01
• Publication Date (W3CDTF): 2014-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2014-12-17
• Date Granted (W3CDTF): 2014-12-17
• Dissertation Number: 甲医学第1693号
• Degree Type: 博士 (医学)
• Conferring No. (Dissertation): 甲医学第1693号
• Text Language Code: eng
• Alias of Author: イシハラ, ミキヤ; 石原, 幹也
• Target Audience: 一般
• Note (General): application/pdf; Oncolytic virotherapy combined with immunomodulators is a novel noninvasive strategy for cancer treatment. In this study, we examined the tumoricidal effects of oncolytic HF10, a naturally occurring mutant of herpes simplex virus type-1, combined with an agonistic DTA-1 monoclonal antibody specific for the glucocorticoid-induced tumor necrosis factor receptor. Two murine tumor models were used to evaluate the therapeutic efficacies of HF10 virotherapy combined with DTA-1. The kinetics and immunological mechanisms of DTA-1 in HF10 infection were examined using flow cytometry and immunohistochemistry. Intratumoral administration of HF10 in combination with DTA-1 at a low dose resulted in a more vigorous attenuation of growth of the untreated contralateral as well as the treated tumors than treatment with either HF10 or DTA-1 alone. An accumulation of CD8(+) T cells, including tumor- and herpes simplex virus type-1-specific populations, and a decrease in the number of CD4(+) Foxp3(+) T regulatory cells were seen in both HF10- and DTA-1-treated tumors. Studies using Fc-digested DTA-1 and Fc gamma receptor knockout mice demonstrated the direct participation of DTA-1 in regulatory T cell depletion by antibody-dependent cellular cytotoxicity primarily via macrophages. These results indicated the potential therapeutic efficacy of a glucocorticoid-induced tumor necrosis factor receptor-specific monoclonal antibody in oncolytic virotherapy at local tumor sites.; 本文 / Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan; 18p; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104669
• DOI: info:doi/10.1371/journal.pone.0104669; https://doi.org/info:doi/10.1371/journal.pone.0104669
• Persistent ID (NDL): info:ndljp/pid/9529698; https://dl.ndl.go.jp/pid/9529698
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-11-01T14:53:18+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104669
• Periodical Title (URI): http://hdl.handle.net/10076/14717; https://mie-u.repo.nii.ac.jp/records/7826
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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