Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression

• Material Type: 博士論文
• Title: Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression
• Author/Editor: Kuroyanagi, Junya
• Author Heading: Kuroyanagi, Junya
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2014-01-01
• Publication Date (W3CDTF): 2014-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2014-12-17
• Date Granted (W3CDTF): 2014-12-17
• Dissertation Number: 甲医学第1696号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1696号
• Text Language Code: eng
• Alias of Author: クロヤナギ, ジュンヤ; 黒栁, 淳哉
• Subject Heading: Prostate cancer; Tumour vessels; Xenotransplantation; Zebrafish; DNA microarray
• Target Audience: 一般
• Note (General): application/pdf; Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.; 本文 / Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine; 8p; http://www.sciencedirect.com/science/article/pii/S0014579315000903
• DOI: info:doi/10.1016/j.febslet.2015.02.010; https://doi.org/info:doi/10.1016/j.febslet.2015.02.010
• Persistent ID (NDL): info:ndljp/pid/9529836; https://dl.ndl.go.jp/pid/9529836
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-11-01T14:53:18+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://www.sciencedirect.com/science/article/pii/S0014579315000903
• Periodical Title (URI): http://hdl.handle.net/10076/14720; https://mie-u.repo.nii.ac.jp/records/7829
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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