Impact of Chronic Kidney Disease on the Presence and Severity of Aortic Stenosis in Patients at High Risk for Coronary Artery Disease

• Material Type: 博士論文
• Title: Impact of Chronic Kidney Disease on the Presence and Severity of Aortic Stenosis in Patients at High Risk for Coronary Artery Disease
• Author/Editor: Masuda, Chiaki
• Author Heading: Masuda, Chiaki
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2015-01-01
• Publication Date (W3CDTF): 2015-01-01
• Degree grantor/type: 三重大学
• Date Granted: 2015-03-25
• Date Granted (W3CDTF): 2015-03-25
• Dissertation Number: 乙医学第978号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第978号
• Text Language Code: eng
• Alias of Author: マスダ, チアキ; 増田, 千秋
• Subject Heading: Echocardiography; Aortic valve area; Coronary artery disease; Chronic kidney disease
• Target Audience: 一般
• Note (General): application/pdf; Objective: We evaluated the impact of chronic kidney disease (CKD) on the presence and severity of aorticstenosis (AS) in patients at high risk for coronary artery disease (CAD).Methods: One hundred and twenty consecutive patients who underwent invasive coronary angiography wereenrolled. Aortic valve area (AVA) was calculated by the continuity equation using transthoracic echocardiography,and was normalized by body surface area (AVA index).Results: Among all 120 patients, 78% had CAD, 55% had CKD (stage 3: 81%; stage 4: 19%), and 34% had AS (AVA <2.0cm2). Patients with AS were older, more often female, and had a higher frequency of CKD than those without AS,but the prevalence of CAD and most other coexisting conventional risk factors was similar between patients with andwithout AS. Multivariate linear regression analysis indicated that only CKD and CAD were independent determinants ofAVA index with standardized coefficients of -0.37 and -0.28, respectively. When patients were divided into 3 groups(group 1: absence of CKD and CAD, n = 16; group 2: presence of either CKD or CAD, n = 51; and group 3: presence ofboth CKD and CAD, n = 53), group 3 had the smallest AVA index (1.19 ± 0.30*# cm2/m2, *p < 0.05 vs. group 1: 1.65 ±0.32 cm2/m2, and #p < 0.05 vs. group 2: 1.43 ± 0.29* cm2/m2) and the highest peak velocity across the aortic valve(1.53 ± 0.41*# m/sec; *p < 0.05 vs. group 1: 1.28 ± 0.29 m/sec, and #p < 0.05 vs. group 2: 1.35 ± 0.27 m/sec).Conclusion: CKD, even pre-stage 5 CKD, has a more powerful impact on the presence and severity of AS thanother conventional risk factors for atherosclerosis in patients at high risk for CAD.; 本文 / Central Laboratory, Mie University Graduate School of Medicine; 9p; http://www.cardiovascularultrasound.com/content/9/1/31
• DOI: info:doi/10.1186/1476-7120-9-31; https://doi.org/info:doi/10.1186/1476-7120-9-31
• Persistent ID (NDL): info:ndljp/pid/9530070; https://dl.ndl.go.jp/pid/9530070
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-11-01T14:53:18+09:00
• Date Created (W3CDTF): 2017-02-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://www.cardiovascularultrasound.com/content/9/1/31
• Periodical Title (URI): http://hdl.handle.net/10076/14730; https://mie-u.repo.nii.ac.jp/records/7837
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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