MLH1発現抑制とそれに伴うPMS2の発現低下が神経膠芽腫のTMZ耐性獲得に寄与する

• Material Type: 博士論文
• Title: MLH1発現抑制とそれに伴うPMS2の発現低下が神経膠芽腫のTMZ耐性獲得に寄与する
• Volume: 4 12
• Author/Editor: 新里, 能成
• Author Heading: 新里, 能成
• Publication, Distribution, etc.: Oncotarget
• Publication Date: 2013; 4 12
• Publication Date (W3CDTF): 2013
• Alternative Title: Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma
• Periodical title: Oncotarget
• Degree grantor/type: 鹿児島大学
• Date Granted: 2014-03-18
• Date Granted (W3CDTF): 2014-03-18
• Dissertation Number: 甲総研第270号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第270号
• Text Language Code: eng
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GBM), it remains unclear which molecule is associated with GBM recurrence. We isolated three TMZ-resistant human GBM cell lines and examined the expression of O6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair (MMR) components. We used immunohistochemical analysis to compare MutL homolog 1 (MLH1), postmeiotic segregation increased 2 (PMS2) and MGMT expression in primary and recurrent GBM specimens obtained from GBM patients during TMZ treatment. We found a reduction in MLH1 expression and a subsequent reduction in PMS2 protein levels in TMZ-resistant cells. Furthermore, MLH1 or PMS2 knockdown confered TMZ resistance. In recurrent GBM tumours, the expression of MLH1 and PMS2 was reduced when compared to primary tumours.Yoshinari Shinsato, Tatsuhiko Furukawa, Shunji Yunoue, Hajime Yonezawa, Kentarou Minami, Yukihiko Nishizawa, Ryuji Ikeda, Kohichi Kawahara, Masatatsu Yamamoto, Hirofumi Hirano, Hiroshi Tokimura, and Kazunori AritaReduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastomaOncotarget 4(12) 2013doi: https://doi.org/10.18632/oncotarget.1302
• DOI: info:doi/10.18632/oncotarget.1302; https://doi.org/info:doi/10.18632/oncotarget.1302
• Persistent ID (NDL): info:ndljp/pid/9550388; https://dl.ndl.go.jp/pid/9550388
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-12-01T13:36:39+09:00
• Date Created (W3CDTF): 2016-10-27
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/25219
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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