脊椎動物特異的シナプス接着分子Netrin-G/NGLによるシナプス機能多様化機構

• Material Type: 博士論文
• Title: 脊椎動物特異的シナプス接着分子Netrin-G/NGLによるシナプス機能多様化機構
• Author/Editor: 松川, 浩
• Author Heading: 松川, 浩
• Publication, Distribution, etc.: Society for Neuroscience
• Publication Date: 2015-03-18
• Publication Date (W3CDTF): 2015-03-18
• Alternative Title: Netrin-G/NGL Complexes Encode Functional Synaptic Diversification
• Degree Grantor: 鹿児島大学
• Date Granted: 2015-03-18
• Date Granted (W3CDTF): 2015-03-18
• Dissertation Number: 乙総論第20号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: excitatory synapse; mice; netrin-G1; netrin-G2; pathway specificity; trans-synaptic adhesion molecule
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨; Synaptic cell adhesion molecules are increasingly gaining attention for conferring specific properties to individual synapses. Netrin-G1 and netrin-G2 are trans-synaptic adhesion molecules that distribute on distinct axons, and their presence restricts the expression of their cognate receptors, NGL1 and NGL2, respectively, to specific subdendritic segments of target neurons. However, the neural circuits and functional roles of netrin-G isoform complexes remain unclear. Here, we use netrin-G-KO and NGL-KO mice to reveal that netrin-G1/NGL1and netrin-G2/NGL2 interactions specify excitatory synapses in independent hippocampal pathways. In the hippocampalCA1area, netrin-G1/NGL1 and netrin-G2/NGL2 were expressed in the temporoammonic and Schaffer collateral pathways, respectively. The lack of presynaptic netrin-Gs led to the dispersion of NGLs from postsynaptic membranes. In accord, netrin-G mutant synapses displayed opposing phenotypes in long-term and short-term plasticity through discrete biochemical pathways. The plasticity phenotypes in netrin-G-KOs were phenocopied in NGL-KOs, with a corresponding loss of netrin-Gs from presynaptic membranes. Our findings show that netrin-G/NGL interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms and explain how synaptic inputs are diversified to control neuronal activity.Hiroshi Matsukawa, Sachiko Akiyoshi-Nishimura, Qi Zhang, Rafael Luján, Kazuhiko Yamaguchi, Hiromichi Goto, Kunio Yaguchi, Tsutomu Hashikawa, Chie Sano, Ryuichi Shigemoto, Toshiaki Nakashiba and Shigeyoshi ItoharaNetrin-G/NGL Complexes Encode Functional Synaptic DiversificationJournal of Neuroscience 2014, 34 (47) p.15779-15792DOI: https://doi.org/10.1523/JNEUROSCI.1141-14.2014
• Persistent ID (NDL): info:ndljp/pid/9550399; https://dl.ndl.go.jp/pid/9550399
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/25483
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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