Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study

• Material Type: 博士論文
• Title: Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study
• Author/Editor: Shimizu, Yoshiyuki
• Author Heading: Shimizu, Yoshiyuki
• Publication, Distribution, etc.: OMICS International
• Publication Date: 2014
• Publication Date (W3CDTF): 2014
• Alternative Title: 活動中の騒音曝露と生体ラット脳内での神経新生 : 予備的検討
• Periodical title: Journal of Neurology & Neurophysiology
• Degree grantor/type: 浜松医科大学
• Date Granted: 2015-03-16
• Date Granted (W3CDTF): 2015-03-16
• Dissertation Number: 甲第696号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第696号
• Text Language Code: eng
• Subject Heading: Neurogenesis; Noise; Rat; [18F]FLT; Positron emission tomography; subventricular zone; hippocampal subgranular zone
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Objective: The effects of loud noise (80 dB) on neurogenesis in the subventricular zone (SVZ) and the hippocampal subgranular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography (PET) with 3’-deoxy-3’-[18F]fluoro-L-thymidine ([18F]FLT), a marker for thymidine kinase I (TK-1) related to cell proliferation and for neurogenesis in SVZ and SGZ.Methods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed 4 days after the exposure.Results: The accumulation of [18F]FLT in SVZ was significantly lower in the rats with noise exposure than in the control rats. The level of [18F]FLT uptake was lower in the SVZ than in the SGZ.Conclusion: Our results indicate that loud noise exposure during the awake period may be related to the decrease in proliferative capacity of neural stem cells especially in the SVZ of the living rat brain. This finding may indicate that persistent loud noise during daily life is harmful to brain development in humans.
• DOI: info:doi/10.4172/2155-9562; https://doi.org/info:doi/10.4172/2155-9562
• Persistent ID (NDL): info:ndljp/pid/9550892; https://dl.ndl.go.jp/pid/9550892
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-12-01T13:36:39+09:00
• Date Created (W3CDTF): 2018-08-27
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/2904; https://hama-med.repo.nii.ac.jp/records/2765
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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