Effects of β-estradiol on cold-sensitive receptor channel TRPM8 in ovariectomized rats.

• Material Type: 博士論文
• ISSN: 1341-1357
• Title: Effects of β-estradiol on cold-sensitive receptor channel TRPM8 in ovariectomized rats.
• Volume: 66 4
• Author/Editor: KUBO, Takuro
• Author Heading: KUBO, Takuro
• Publication, Distribution, etc.: Japanese Association for Laboratory Animal Science
• Publication Date: 2017
• Publication Date (W3CDTF): 2017
• Periodical title: Experimental Animals
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2017-09-13
• Date Granted (W3CDTF): 2017-09-13
• Dissertation Number: 乙第433号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第433号
• Text Language Code: eng
• Subject Heading: cold-sensitive TRPM8 channel receptor; estrogen; estrogen replacement; oversensitivity to cold; post-menopause
• Target Audience: 一般
• Note (General): Transient receptor potential cation channel subfamily M member 8 (TRPM8) is associated with sensitivity to cold sensation in mammals. A previous study demonstrated that TRPM8 was overexpressed in the skin of ovariectomized (OVX) rats due to the loss of estrogen. In the present study, we investigated whether estrogen replacement restricts overexpression of the TRPM8 channel in the skin of OVX rats. We divided 15 Sprague Dawley rats into three groups: a non-operated group (NON-OPE), an ovariectomy group (OVX), and a group subjected to estrogen replacement during 4 weeks beginning 7 days after ovariectomy (OVX + E2). Five weeks later, TRPM8 channel mRNA and protein in lumbar skin were quantified by real-time RT-PCR, protein ELISA, and immunohistochemistry. The OVX + E2 group exhibited a trend for decreased expression of the TRPM8 channel in the lumbar skin in comparison with the OVX group, whereas ELISA data and immunohistochemistry data and immunohistochemistry graphs relating to TRPM8 protein did not show any obvious differences between the OVX group and the OVX + E2 group. Estrogen replacement may restrict the overexpression of TRPM8 in the dermis of OVX rats.; Thesis or Dissertation; 平成29年度; 10.1538/expanim.17-0028; J-STAGE
• DOI: info:doi/10.1538/expanim.17-0028; https://doi.org/info:doi/10.1538/expanim.17-0028
• Persistent ID (NDL): info:ndljp/pid/9550896; https://dl.ndl.go.jp/pid/9550896
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2015-12-01T13:36:39+09:00
• Date Created (W3CDTF): 2017-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.jstage.jst.go.jp/article/expanim/66/4/66_17-0028/_article
• Periodical Title (URI): http://hdl.handle.net/10422/10971; https://shiga-med.repo.nii.ac.jp/records/2897
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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